Literature DB >> 31063396

Lipid Nanoparticles for Delivery of Therapeutic RNA Oligonucleotides.

Keith Henry Moss1, Petya Popova2, Sine R Hadrup1, Kira Astakhova2, Maria Taskova2.   

Abstract

Gene therapy is an exciting field that has the potential to address emerging scientific and therapeutic tasks. RNA-based gene therapy has made remarkable progress in recent decades. Nevertheless, efficient targeted delivery of RNA therapeutics is still a prerequisite for entering the clinics. In this review, we introduce current delivery methods for RNA gene therapeutics based on lipid nanoparticles (LNPs). We focus on the clinical appeal of recent RNA NPs and discuss existing challenges of fabrication and screening LNP candidates for effective translation into drugs of human metabolic diseases and cancer.

Entities:  

Keywords:  LNP fabrication; LNP screening; RNA; delivery; gene therapy; lipid nanoparticle (LNP)

Mesh：

Substances：

Year:  2019        PMID： 31063396     DOI： 10.1021/acs.molpharmaceut.8b01290

Source DB:  PubMed          Journal:  Mol Pharm        ISSN： 1543-8384            Impact factor:   4.939


  18 in total

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Journal:  Nat Cancer       Date:  2020-08-10

2.  Lipid nanoparticle-mediated lymph node-targeting delivery of mRNA cancer vaccine elicits robust CD8+ T cell response.

Authors:  Jinjin Chen; Zhongfeng Ye; Changfeng Huang; Min Qiu; Donghui Song; Yamin Li; Qiaobing Xu
Journal:  Proc Natl Acad Sci U S A       Date:  2022-08-15       Impact factor: 12.779

Review 3.  Microfluidic fabrication of lipid nanoparticles for the delivery of nucleic acids.

Authors:  Gyan Prakash; Ahmed Shokr; Niels Willemen; Showkeen Muzamil Bashir; Su Ryon Shin; Shabir Hassan
Journal:  Adv Drug Deliv Rev       Date:  2022-03-12       Impact factor: 17.873

Review 4.  Nanomaterials for cancer therapy: current progress and perspectives.

Authors:  Zhe Cheng; Maoyu Li; Raja Dey; Yongheng Chen
Journal:  J Hematol Oncol       Date:  2021-05-31       Impact factor: 17.388

Review 5.  New approaches to moderate CRISPR-Cas9 activity: Addressing issues of cellular uptake and endosomal escape.

Authors:  Maja van Hees; Sofie Slott; Anders Højgaard Hansen; Heon Seok Kim; Hanlee P Ji; Kira Astakhova
Journal:  Mol Ther       Date:  2021-06-04       Impact factor: 11.454

6.  Biodistribution of Nanostructured Lipid Carriers in Mice Atherosclerotic Model.

Authors:  Laurent Devel; Gunter Almer; Claudia Cabella; Fabrice Beau; Mylène Bernes; Paolo Oliva; Fabrice Navarro; Ruth Prassl; Harald Mangge; Isabelle Texier
Journal:  Molecules       Date:  2019-09-26       Impact factor: 4.411

7.  The Importance of Poly(ethylene glycol) and Lipid Structure in Targeted Gene Delivery to Lymph Nodes by Lipid Nanoparticles.

Authors:  Danijela Zukancic; Estelle J A Suys; Emily H Pilkington; Azizah Algarni; Hareth Al-Wassiti; Nghia P Truong
Journal:  Pharmaceutics       Date:  2020-11-09       Impact factor: 6.321

Review 8.  Delivery of cancer therapies by synthetic and bio-inspired nanovectors.

Authors:  Tina Briolay; Tacien Petithomme; Morgane Fouet; Nelly Nguyen-Pham; Christophe Blanquart; Nicolas Boisgerault
Journal:  Mol Cancer       Date:  2021-03-24       Impact factor: 27.401

9.  Delivery of antisense oligonucleotide using polyethylenimine-based lipid nanoparticle modified with cell penetrating peptide.

Authors:  Shuang Yang; Dandan Wang; Yaojun Sun; Bin Zheng
Journal:  Drug Deliv       Date:  2019-12       Impact factor: 6.419

Review 10.  Biodegradable Polymers for Gene-Delivery Applications.

Authors:  Chih-Kuang Chen; Ping-Kuan Huang; Wing-Cheung Law; Chia-Hui Chu; Nai-Tzu Chen; Leu-Wei Lo
Journal:  Int J Nanomedicine       Date:  2020-03-30
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