| Literature DB >> 31063383 |
Xingyue Ji1,2, Robert E Aghoghovbia1, Ladie Kimberly C De La Cruz1, Zhixiang Pan1, Xiaoxiao Yang1, Bingchen Yu1, Binghe Wang1.
Abstract
A high-content bioorthogonal prodrug with multiple outputs using the "click, cyclize, and release" concept is described. The proof of concept is established by the co-delivery of a gasotransmitter carbon monoxide, an anticancer drug floxuridine, and an in situ generated fluorescent reporter molecule for real-time monitoring of the prodrug activation. Bioorthogonal prodrugs as such are invaluable tools for the co-delivery of other drug payloads for multimodal therapy.Entities:
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Year: 2019 PMID： 31063383 DOI： 10.1021/acs.orglett.9b01086
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005