E Cumbo1, S Cumbo, S Torregrossa, D Migliore. 1. Eduardo Cumbo, Neurodegenerative Disorders Unit, ASP 2 Caltanissetta, via L.Monaco 109 Caltanissetta (Italy);email: eduardo.cumbo@tiscali.it; tel. +39 0934506309/0934 506321.
Abstract
BACKGROUND/ OBJECTIVES:depressive symptoms are common in Alzheimer's disease(AD). Aim of the study was to investigate the efficacy of vortioxetine compared with other conventional antidepressants on cognitive functions in AD patients with depressive symptoms. DESIGN: Prospective, randomized, 12 month, parallel-group study. SETTING:All participants were evaluated on-site at Neurodegenerative Disorders Unit, ASP2 Caltanissetta(Italy). PARTICIPANTS: 108(71 female, 37 male) AD patients with depression(mean age 76.7 ± 4.3). INTERVENTION: Randomized subjects received vortioxetine, 15 mg/day(n=36) or other common antidepressants(n=72). MEASURES: Primary outcome was change from baseline in the MMSE; secondary outcomes were change in Attentive Matrices, Raven Coloured Progressive Matrices, Digit Span, HAM-D and Cornell scale. RESULTS: Statistically significant improvement vs. controls was observed for vortioxetine on most of the cognitive tests and showed significantly baseline-to-endpoint reduction in both HAM-D and Cornell total scores.The most commonly reported adverse events were nausea and headache for votioxetine; nausea in the control group. CONCLUSIONS:Vortioxetine had a beneficial effect on cognition and mood in elderly AD patients and was safe and well tolerated.
RCT Entities:
BACKGROUND/ OBJECTIVES:depressive symptoms are common in Alzheimer's disease(AD). Aim of the study was to investigate the efficacy of vortioxetine compared with other conventional antidepressants on cognitive functions in ADpatients with depressive symptoms. DESIGN: Prospective, randomized, 12 month, parallel-group study. SETTING: All participants were evaluated on-site at Neurodegenerative Disorders Unit, ASP2 Caltanissetta(Italy). PARTICIPANTS: 108(71 female, 37 male) ADpatients with depression(mean age 76.7 ± 4.3). INTERVENTION: Randomized subjects received vortioxetine, 15 mg/day(n=36) or other common antidepressants(n=72). MEASURES: Primary outcome was change from baseline in the MMSE; secondary outcomes were change in Attentive Matrices, Raven Coloured Progressive Matrices, Digit Span, HAM-D and Cornell scale. RESULTS: Statistically significant improvement vs. controls was observed for vortioxetine on most of the cognitive tests and showed significantly baseline-to-endpoint reduction in both HAM-D and Cornell total scores.The most commonly reported adverse events were nausea and headache for votioxetine; nausea in the control group. CONCLUSIONS:Vortioxetine had a beneficial effect on cognition and mood in elderly ADpatients and was safe and well tolerated.
Authors: Luis Agüera-Ortiz; Rocío García-Ramos; Francisco J Grandas Pérez; Jorge López-Álvarez; José Manuel Montes Rodríguez; F Javier Olazarán Rodríguez; Javier Olivera Pueyo; Carmelo Pelegrin Valero; Jesús Porta-Etessam Journal: Front Psychiatry Date: 2021-02-26 Impact factor: 4.157