Literature DB >> 3106082

Insulin but not phorbol ester treatment increases phosphorylation of vinculin by protein kinase C in BC3H-1 myocytes.

D R Cooper, C M de Ruiz Galaretta, L F Fanjul, L Mojsilovic, M L Standaert, R J Pollet, R V Farese.   

Abstract

Insulin was found to increase protein kinase C activity in BC3H-1 myocytes as determined by in vitro phosphorylation of both a lysine-rich histone fraction (histone III-S) and vinculin. TPA treatment for 20 min or 18 h provoked an apparent loss of histone-directed but not vinculin-directed phosphorylation by cytosolic C-kinase. Thus, chronic TPA-induced 'desensitization' or 'depletion' of cellular protein kinase C is more apparent than real, and is not a valid means for evaluating the role of C-kinase in hormone action.

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Year:  1987        PMID： 3106082     DOI： 10.1016/0014-5793(87)80025-x

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  7 in total

Review 1.  Specific protein kinase C isoforms as transducers and modulators of insulin signaling.

Authors:  Sanford R Sampson; Denise R Cooper
Journal:  Mol Genet Metab       Date:  2006-06-23       Impact factor: 4.797

2.  Characterization of bovine aortic protein kinase C with histone and platelet protein P47 as substrates.

Authors:  K R Dell; M P Walsh; D L Severson
Journal:  Biochem J       Date:  1988-09-01       Impact factor: 3.857

Review 3.  From animal to molecule: aspects of the biology of insulin-like growth factors.

Authors:  R S Gilmour; C G Prosser; I R Fleet; L Cocco; J C Saunders; K D Brown; A N Corps
Journal:  Br J Cancer Suppl       Date:  1988-12

4.  Insulin-like effects of epidermal growth factor and insulin-like growth factor-I on [3H]2-deoxyglucose uptake, diacylglycerol generation and protein kinase C activation in BC3H-1 myocytes.

Authors:  R V Farese; G P Nair; C G Sierra; M L Standaert; R J Pollet; D R Cooper
Journal:  Biochem J       Date:  1989-08-01       Impact factor: 3.857

5.  Phorbol esters inhibit insulin-induced receptor down-regulation in cultured human lymphocytes: association with diminished insulin receptor autophosphorylation.

Authors:  K Torossian; P Nower; T Schwartz; I G Fantus
Journal:  Biochem J       Date:  1993-02-15       Impact factor: 3.857

6.  Mechanisms whereby insulin increases diacylglycerol in BC3H-1 myocytes.

Authors:  R V Farese; D R Cooper; T S Konda; G Nair; M L Standaert; J S Davis; R J Pollet
Journal:  Biochem J       Date:  1988-11-15       Impact factor: 3.857

7.  Comparison of effects of phorbol esters and glucose on protein kinase C activation and insulin secretion in pancreatic islets.

Authors:  R A Easom; J H Hughes; M Landt; B A Wolf; J Turk; M L McDaniel
Journal:  Biochem J       Date:  1989-11-15       Impact factor: 3.857
  7 in total

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