Literature DB >> 3106043

Improved tumor localization of 111In labeled monoclonal antibody with chelator administration to host nude mice.

A Lockshin, J S Stehlin.   

Abstract

Administration of calcium disodium edetate (EDTA) substantially increased the tumor:muscle ratios of nude mice injected with 111In labeled monoclonal antibody 9.2.27. This effect was apparent 3 days to 7 days after antibody injection of mice bearing the BRO human melanoma, but not earlier. The tumor:muscle ratios decreased during this time for animals not receiving chelator. Contemporaneously, EDTA treated mice lost whole body radioactivity more rapidly than did their untreated counterparts, suggesting that 111In which had dissociated from the antibody-DTPA-radiometal complex was chelated and excreted. These results suggest that effective chelator treatment might improve tumor localization of radioactivity after injection of 111In labeled antibodies.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 3106043     DOI： 10.1007/bf00296100

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  10 in total

1.  111 In-chloride: a new agent for bone marrow imaging.

Authors:  D L Lilien; H G Berger; D P Anderson; L R Bennett
Journal:  J Nucl Med       Date:  1973-03       Impact factor: 10.057

2.  Production and characterization of monoclonal antibody to a melanoma specific glycoprotein.

Authors:  A C Morgan; D R Galloway; R A Reisfeld
Journal:  Hybridoma       Date:  1981

3.  The influence of ligand on the tissue distribution of carrier free 111In in the rat.

Authors:  M V Merrick; A D Nunn; M L Thakur; S W Gunasekera
Journal:  Int J Nucl Med Biol       Date:  1975-01

4.  Differences in tumour and normal tissue concentrations of iodine- and indium-labelled monoclonal antibody. II. Biodistribution studies in mice with human tumour xenografts.

Authors:  M V Pimm; A C Perkins; R W Baldwin
Journal:  Eur J Nucl Med       Date:  1985

5.  Determination of cytotoxicity in vivo using 111indium-labeled human tumor cells.

Authors:  A Lockshin; B C Giovanella; T Kozielski; J S Stehlin
Journal:  Cancer Lett       Date:  1984-09       Impact factor: 8.679

6.  Stability, characterization, and kinetics of 111In-labeled monoclonal antitumor antibodies in normal animals and nude mouse-human tumor models.

Authors:  S E Halpern; P L Hagan; P R Garver; J A Koziol; A W Chen; J M Frincke; R M Bartholomew; G S David; T H Adams
Journal:  Cancer Res       Date:  1983-11       Impact factor: 12.701

7.  Correlation of cytotoxicity with elimination of iodine-125 from nude mice inoculated with prelabeled human melanoma cells.

Authors:  A Lockshin; B C Giovanella; C Quian; J T Mendoza; D M Vardeman; J S Stehlin
Journal:  J Natl Cancer Inst       Date:  1984-08       Impact factor: 13.506

8.  Prediction of anticancer activity by tumor uptake of radiolabeled monoclonal antibody.

Authors:  A Lockshin; T Kozielski; J S Stehlin
Journal:  Cancer Lett       Date:  1986-01       Impact factor: 8.679

9.  Radioimmunoimaging in malignant melanoma with 111In-labeled monoclonal antibody 96.5.

Authors:  J L Murray; M G Rosenblum; R E Sobol; R M Bartholomew; C E Plager; T P Haynie; M F Jahns; H J Glenn; L Lamki; R S Benjamin
Journal:  Cancer Res       Date:  1985-05       Impact factor: 12.701

10.  Exceptional lethality for nude mice of cells derived from a primary human melanoma.

Authors:  A Lockshin; B C Giovanella; P D De Ipolyi; L J Williams; J T Mendoza; S O Yim; J S Stehlin
Journal:  Cancer Res       Date:  1985-01       Impact factor: 12.701
  10 in total
  1 in total

1.  In vitro and in vivo effects of diethylene triamine penta-acetic acid on the distribution of indium-111 monoclonal antibody metabolism.

Authors:  Y Kimura; T Fujii; K Ochi; A Akamune; K Hamamoto
Journal:  Eur J Nucl Med       Date:  1992
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.