Literature DB >> 31059273

Synthesis of Exclusively 4-Substituted β-Lactams through the Kinugasa Reaction Utilizing Calcium Carbide.

Abolfazl Hosseini1, Peter R Schreiner1.   

Abstract

A new Kinugasa reaction protocol has been elaborated for the one-pot synthesis of 4-substituted β-lactams utilizing calcium carbide and nitrone derivatives. Calcium carbide is thereby activated by TBAF·3H2O in the presence of CuCl/NMI. The ease of synthesis and use of inexpensive chemicals provides rapid access of practical quantities of β-lactams exclusively substituted at position 4.

Entities:  

Year:  2019        PMID： 31059273     DOI： 10.1021/acs.orglett.9b01192

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  2 in total

1.  Thermal and Microwave-Assisted Synthesis of New Highly Functionalized Bis-β-lactams from Available Compounds via Bisketene as an Intermediate.

Authors:  Hakimeh Hassani Nadiki; Mohammad Reza Islami; Sara Soltanian
Journal:  ACS Omega       Date:  2022-09-08

2.  Towards Sustainable Carbon Return from Waste to Industry via C2-Type Molecular Unit.

Authors:  Konstantin S Rodygin; Kristina A Lotsman; Dmitriy E Samoylenko; Viktor M Kuznetsov; Valentine P Ananikov
Journal:  Int J Mol Sci       Date:  2022-10-05       Impact factor: 6.208
  2 in total

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