BACKGROUND: Treatment of the uninvolved neck in well-lateralized tonsillar squamous cell carcinoma is controversial. We became concerned after a number of contralateral neck recurrences (CNRs) in patients receiving ipsilateral radiotherapy (RT). METHODS: This is a single center retrospective series including patients with well-lateralized tonsillar cancer treated with ipsilateral neck RT between 2004 and 2011. RESULTS: We identified 53 patients treated with ipsilateral neck RT during the study period. The rate of CNR was 7.5% (4 of 53). All four patients had p16-positive, T1, N2b, M0 tumors. The subgroup of patients with N2b disease (28 of 53) had a CNR of 14.3%. We subsequently switched to treat patients with N2b with bilateral neck RT. We analyzed the outcomes of 23 patients with N2b treated with bilateral neck intensity-modulated RT (IMRT) and observed no CNRs. CONCLUSIONS: We observed a higher than expected rate of CNR in the N2b population. Bilateral neck IMRT for these patients represents a safe alternative.
BACKGROUND: Treatment of the uninvolved neck in well-lateralized tonsillar squamous cell carcinoma is controversial. We became concerned after a number of contralateral neck recurrences (CNRs) in patients receiving ipsilateral radiotherapy (RT). METHODS: This is a single center retrospective series including patients with well-lateralized tonsillar cancer treated with ipsilateral neck RT between 2004 and 2011. RESULTS: We identified 53 patients treated with ipsilateral neck RT during the study period. The rate of CNR was 7.5% (4 of 53). All four patients had p16-positive, T1, N2b, M0 tumors. The subgroup of patients with N2b disease (28 of 53) had a CNR of 14.3%. We subsequently switched to treat patients with N2b with bilateral neck RT. We analyzed the outcomes of 23 patients with N2b treated with bilateral neck intensity-modulated RT (IMRT) and observed no CNRs. CONCLUSIONS: We observed a higher than expected rate of CNR in the N2b population. Bilateral neck IMRT for these patients represents a safe alternative.
Authors: Nicolette Taku; Gregory Chronowski; G Brandon Gunn; William H Morrison; Neil D Gross; Amy C Moreno; Renata Ferrarotto; Steven J Frank; C David Fuller; Ryan P Goepfert; Jack Phan; Stephen Y Lai; Jay P Reddy; David I Rosenthal; Adam S Garden Journal: Int J Radiat Oncol Biol Phys Date: 2022-05-02 Impact factor: 8.013
Authors: C Jillian Tsai; Thomas J Galloway; Danielle N Margalit; Richard L Bakst; Beth M Beadle; Jonathan J Beitler; Steven Chang; Allen Chen; Jay Cooper; Shlomo A Koyfman; John A Ridge; Jared Robbins; Minh Tam Truong; Sue S Yom; Farzan Siddiqui Journal: Head Neck Date: 2020-10-17 Impact factor: 3.821
Authors: Jared H Hara; Stanley I Gutiontov; Sophia Uddin; Ari J Rosenberg; Alexander T Pearson; Zhen Gooi; Elizabeth A Blair; Nishant Agrawal; Everett E Vokes; Daniel T Ginat; Daniel J Haraf; Aditya Juloori Journal: Cureus Date: 2022-07-31
Authors: Axel Sahovaler; John J W Lee; Wei Xu; Susie Su; Ali Hosni; Andrew Bayley; David P Goldstein; John R de Almeida Journal: J Otolaryngol Head Neck Surg Date: 2021-12-23