Waleska Barros1,2, Mirian David1, Ana Souza3, Mariluce Silva3, Rhowena Matos1,4. 1. Programa de Pós-Graduação em Neuropsiquiatria e Ciências do Comportamento, Universidade Federal de Pernambuco (UFPE), Recife, Brazil. 2. CITENC (Centro integrado de tecnologia em neurociência), Centro Integrado de Tecnologia e Pesquisa (CINTEP) - Centro Universitário Osman Lins (FACOL), Vitória de Santo Antão, Brazil. 3. Fisioterapia, Centro Universitário Osman Lins (FACOL), Vitória de Santo Antão, Brazil. 4. Núcleo de Educação Física e Ciências do Esporte, Universidade Federal de Pernambuco Centro Acadêmico de Vitória (CAV), Vitória de Santo Antão, Brazil.
Abstract
BACKGROUND AND AIM: Environmental enrichment (EE) can be related to changes in the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus of adult rodents. Exposure to EE may also induce neurogenesis in the dentate gyrus (DG). The aim of this systematic review was to analyze the current literature on the correlation between neurogenesis and BDNF expression in the hippocampal DG region resulting from exposure to EE, which is associated with changes in memory, in rodents. METHODS: Bibliographic searches of the Medline/PubMed and ScienceDirect databases were carried out, and 334 studies were found. A predefined protocol was used and registered on PROSPERO, and 32 studies were included for qualitative synthesis. The PRISMA was used to report this systematic review. RESULTS: Most of the included studies showed that there is little evidence in the literature demonstrating that memory changes resulting from EE are dependent on BDNF expression and that there is an induction of neurogenesis in the hippocampal DG. However, the observed increase in molecular expression levels and cell proliferation is dependent on the age, the timing and duration of exposure to EE. Regarding the methodological quality of the studies, the majority presented a risk of bias due to the high variability in the age of the animals. CONCLUSION: There are few studies in the literature that correlate the molecular and cellular mechanisms involved in neurogenesis in the hippocampal DG with BDNF expression in this region in rodents exposed to EE; however, there are other factors that can modulate this neurogenesis.
BACKGROUND AND AIM: Environmental enrichment (EE) can be related to changes in the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus of adult rodents. Exposure to EE may also induce neurogenesis in the dentate gyrus (DG). The aim of this systematic review was to analyze the current literature on the correlation between neurogenesis and BDNF expression in the hippocampal DG region resulting from exposure to EE, which is associated with changes in memory, in rodents. METHODS: Bibliographic searches of the Medline/PubMed and ScienceDirect databases were carried out, and 334 studies were found. A predefined protocol was used and registered on PROSPERO, and 32 studies were included for qualitative synthesis. The PRISMA was used to report this systematic review. RESULTS: Most of the included studies showed that there is little evidence in the literature demonstrating that memory changes resulting from EE are dependent on BDNF expression and that there is an induction of neurogenesis in the hippocampal DG. However, the observed increase in molecular expression levels and cell proliferation is dependent on the age, the timing and duration of exposure to EE. Regarding the methodological quality of the studies, the majority presented a risk of bias due to the high variability in the age of the animals. CONCLUSION: There are few studies in the literature that correlate the molecular and cellular mechanisms involved in neurogenesis in the hippocampal DG with BDNF expression in this region in rodents exposed to EE; however, there are other factors that can modulate this neurogenesis.
Authors: Karen Corredor; Daniela P Marín; Christian C García; Daniela A Restrepo; Gladys S Martínez; Fernando P Cardenas Journal: J Am Assoc Lab Anim Sci Date: 2022-04-04 Impact factor: 1.706
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