Cutoff values for the determination of sarcopenia and the prevalence of the condition in middle-aged women: A study from Sri Lanka

Introduction: There is a scarcity of studies related to sarcopenia in Sri Lanka. This partly is due to lack of cutoff values to define muscle mass, strength and physical functions. Objective: This cross-sectional study determined the cutoff values of sarcopenia measures and evaluated the prevalence of sarcopenia among middle-aged Sri Lankan women. Method: A reference group of 117 young women (20-40 years) was used for cutoff value determination. The prevalence of sarcopenia was estimated among a group of 270 women (41-60 years). Appendicular Skeletal Muscle Mass (ASMM, kg) was measured by DXA and was adjusted for height (ASMM/height2) to determine Relative Skeletal Muscle mass Index (RSMI, kg/m2). Hand Grip Strength (HGS, kg) and Gait Speed (GS, m/s) were also measured. Cutoff values for measures of sarcopenia were taken as 2SD below the mean value of the young reference group. Result: Mean(SD) ages of the participants; young reference group and middle-aged group were 35.5(3.8) and 52.2(5.8) years respectively. Cutoff values for the main three measures of sarcopenia; RSMI, HGS and GS were 5.03kg/m2, 9.66kg and 0.96m/s respectively. Prevalence of pre-sarcopenia, sarcopenia and severe-sarcopenia among middle-aged women were 3.0%, 2.2%, 0.7% respectively. The corresponding values among postmenopausal women were 4.2%, 3.0%, 1.2% and among premenopausal women were 1.0%, 1.0%, 0.0%. Prevalence of sarcopenia was higher among women aged between 51-60 years and severe sarcopenia was observed only in this age group. Conclusions: This study provides cutoff values for the measures of sarcopenia for Sri Lankan women. Prevalence was higher among postmenopausal women compared to premenopausal women.