Literature DB >> 3105585

Kinetic study on the suicide inactivation of tyrosinase induced by catechol.

F García Cánovas, J Tudela, C Martínez Madrid, R Varón, F García Carmona, J A Lozano.   

Abstract

Tyrosinase has a suicide inactivation reaction when it acts on omicron-diphenols. In the present paper, this reaction has been studied using a transient phase approach. Explicit equations of product vs. time have been developed for the multisubstrate mechanism of tyrosinase, and the kinetic parameters which characterize the enzyme acting on the suicide substrate catechol have been determined. The effect of pH has also been considered.

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Year:  1987        PMID： 3105585     DOI： 10.1016/0167-4838(87)90047-1

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  4 in total

1.  A kinetic study of the suicide inactivation of an enzyme measured through coupling reactions. Application to the suicide inactivation of tyrosinase.

Authors:  J Escribano; J Tudela; F Garcia-Carmona; F Garcia-Canovas
Journal:  Biochem J       Date:  1989-09-01       Impact factor: 3.857

2.  Experimental approach to the kinetic study of unstable site-directed irreversible inhibitors: kinetic origin of the apparent positive co-operativity arising from inactivation of trypsin by p-amidinophenylmethanesulphonyl fluoride.

Authors:  J C Espín; J Tudela
Journal:  Biochem J       Date:  1994-04-01       Impact factor: 3.857

3.  Kinetics of an enzyme reaction in which both the enzyme-substrate complex and the product are unstable or only the product is unstable.

Authors:  C Garrido-del Solo; F García-Cánovas; B H Havsteen; E Valero; R Varón
Journal:  Biochem J       Date:  1994-10-15       Impact factor: 3.857

4.  Mechanism of action of 4-substituted phenols to induce vitiligo and antimelanoma immunity.

Authors:  Arthur Kammeyer; Karin J Willemsen; Wouter Ouwerkerk; Walbert J Bakker; Danielle Ratsma; Sebas D Pronk; Nico P M Smit; Rosalie M Luiten
Journal:  Pigment Cell Melanoma Res       Date:  2019-03-18       Impact factor: 4.693
  4 in total

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