Literature DB >> 31054512

The role of Rab GTPases in the pathobiology of Parkinson' disease.

Luis Bonet-Ponce1, Mark R Cookson2.   

Abstract

Rab GTPases are key regulators of vesicle-mediated transport and are proposed to play a crucial role in the pathobiology of Parkinson's disease. As membrane trafficking seems to be a relevant pathway altered in Parkinson' disease, understanding the role of Rab GTPases in the disease progression could open a window for therapeutic interventions. In this review, we focus on the recent advances on the role of Rab GTPases in the biology of two main proteins involved in Parkinson's disease: LRRK2 and α-synuclein, given that mutations in their genes (LRRK2 and SNCA) cause familial and sporadic Parkinson's disease.
Copyright © 2019 Elsevier Ltd. All rights reserved.

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Year:  2019        PMID： 31054512      PMCID： PMC6726541          DOI： 10.1016/j.ceb.2019.03.009

Source DB:  PubMed          Journal:  Curr Opin Cell Biol        ISSN： 0955-0674            Impact factor:   8.382


  52 in total

Review 1.  Genetic risk factors in Parkinson's disease.

Authors:  K J Billingsley; S Bandres-Ciga; S Saez-Atienzar; A B Singleton
Journal:  Cell Tissue Res       Date:  2018-03-13       Impact factor: 5.249

Review 2.  The role of monogenic genes in idiopathic Parkinson's disease.

Authors:  Xylena Reed; Sara Bandrés-Ciga; Cornelis Blauwendraat; Mark R Cookson
Journal:  Neurobiol Dis       Date:  2018-11-15       Impact factor: 5.996

3.  α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease.

Authors:  Brian Spencer; Changyoun Kim; Tania Gonzalez; Alejandro Bisquertt; Christina Patrick; Edward Rockenstein; Anthony Adame; Seung-Jae Lee; Paula Desplats; Eliezer Masliah
Journal:  Hum Mol Genet       Date:  2016-01-05       Impact factor: 6.150

4.  Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.

Authors:  Mike A Nalls; Nathan Pankratz; Christina M Lill; Chuong B Do; Dena G Hernandez; Mohamad Saad; Anita L DeStefano; Eleanna Kara; Jose Bras; Manu Sharma; Claudia Schulte; Margaux F Keller; Sampath Arepalli; Christopher Letson; Connor Edsall; Hreinn Stefansson; Xinmin Liu; Hannah Pliner; Joseph H Lee; Rong Cheng; M Arfan Ikram; John P A Ioannidis; Georgios M Hadjigeorgiou; Joshua C Bis; Maria Martinez; Joel S Perlmutter; Alison Goate; Karen Marder; Brian Fiske; Margaret Sutherland; Georgia Xiromerisiou; Richard H Myers; Lorraine N Clark; Kari Stefansson; John A Hardy; Peter Heutink; Honglei Chen; Nicholas W Wood; Henry Houlden; Haydeh Payami; Alexis Brice; William K Scott; Thomas Gasser; Lars Bertram; Nicholas Eriksson; Tatiana Foroud; Andrew B Singleton
Journal:  Nat Genet       Date:  2014-07-27       Impact factor: 38.330

5.  Endosomal Rab cycles regulate Parkin-mediated mitophagy.

Authors:  Koji Yamano; Chunxin Wang; Shireen A Sarraf; Christian Münch; Reika Kikuchi; Nobuo N Noda; Yohei Hizukuri; Masato T Kanemaki; Wade Harper; Keiji Tanaka; Noriyuki Matsuda; Richard J Youle
Journal:  Elife       Date:  2018-01-23       Impact factor: 8.140

6.  Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration.

Authors:  Ga Ram Jeong; Eun-Hae Jang; Jae Ryul Bae; Soyoung Jun; Ho Chul Kang; Chi-Hu Park; Joo-Ho Shin; Yukio Yamamoto; Keiko Tanaka-Yamamoto; Valina L Dawson; Ted M Dawson; Eun-Mi Hur; Byoung Dae Lee
Journal:  Mol Neurodegener       Date:  2018-02-13       Impact factor: 14.195

7.  A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain.

Authors:  Herschel S Dhekne; Izumi Yanatori; Rachel C Gomez; Francesca Tonelli; Federico Diez; Birgitt Schüle; Martin Steger; Dario R Alessi; Suzanne R Pfeffer
Journal:  Elife       Date:  2018-11-06       Impact factor: 8.140

8.  LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation.

Authors:  Eun-Jin Bae; Dong-Kyu Kim; Changyoun Kim; Michael Mante; Anthony Adame; Edward Rockenstein; Ayse Ulusoy; Michael Klinkenberg; Ga Ram Jeong; Jae Ryul Bae; Cheolsoon Lee; He-Jin Lee; Byung-Dae Lee; Donato A Di Monte; Eliezer Masliah; Seung-Jae Lee
Journal:  Nat Commun       Date:  2018-08-27       Impact factor: 14.919

9.  Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7.

Authors:  Raul Rojas; Thijs van Vlijmen; Gonzalo A Mardones; Yogikala Prabhu; Adriana L Rojas; Shabaz Mohammed; Albert J R Heck; Graça Raposo; Peter van der Sluijs; Juan S Bonifacino
Journal:  J Cell Biol       Date:  2008-11-03       Impact factor: 10.539

10.  LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis.

Authors:  Tomoya Eguchi; Tomoki Kuwahara; Maria Sakurai; Tadayuki Komori; Tetta Fujimoto; Genta Ito; Shin-Ichiro Yoshimura; Akihiro Harada; Mitsunori Fukuda; Masato Koike; Takeshi Iwatsubo
Journal:  Proc Natl Acad Sci U S A       Date:  2018-09-12       Impact factor: 11.205
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  13 in total

Review 1.  LRRK2 in Parkinson disease: challenges of clinical trials.

Authors:  Eduardo Tolosa; Miquel Vila; Christine Klein; Olivier Rascol
Journal:  Nat Rev Neurol       Date:  2020-01-24       Impact factor: 42.937

Review 2.  Endosomal sorting pathways in the pathogenesis of Parkinson's disease.

Authors:  Lindsey A Cunningham; Darren J Moore
Journal:  Prog Brain Res       Date:  2020-03-16       Impact factor: 2.453

Review 3.  LRRK2 recruitment, activity, and function in organelles.

Authors:  Luis Bonet-Ponce; Mark R Cookson
Journal:  FEBS J       Date:  2021-07-01       Impact factor: 5.622

4.  Crystal structure of human PACRG in complex with MEIG1 reveals roles in axoneme formation and tubulin binding.

Authors:  Nimra Khan; Dylan Pelletier; Thomas S McAlear; Nathalie Croteau; Simon Veyron; Andrew N Bayne; Corbin Black; Muneyoshi Ichikawa; Ahmad Abdelzaher Zaki Khalifa; Sami Chaaban; Igor Kurinov; Gary Brouhard; Susanne Bechstedt; Khanh Huy Bui; Jean-François Trempe
Journal:  Structure       Date:  2021-02-01       Impact factor: 5.871

Review 5.  Rab GTPases: Switching to Human Diseases.

Authors:  Noemi Antonella Guadagno; Cinzia Progida
Journal:  Cells       Date:  2019-08-16       Impact factor: 6.600

6.  Parkinson's disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging.

Authors:  Xi Chen; Chengsong Xie; Wotu Tian; Lixin Sun; Wang Zheng; Sarah Hawes; Lisa Chang; Justin Kung; Jinhui Ding; Shengdi Chen; Weidong Le; Huaibin Cai
Journal:  Mol Neurodegener       Date:  2020-02-19       Impact factor: 14.195

7.  Oligomerization of Lrrk controls actin severing and α-synuclein neurotoxicity in vivo.

Authors:  Souvarish Sarkar; Farah Bardai; Abby L Olsen; Kelly M Lohr; Ying-Yi Zhang; Mel B Feany
Journal:  Mol Neurodegener       Date:  2021-05-24       Impact factor: 14.195

8.  Dysregulation of the AP2M1 phosphorylation cycle by LRRK2 impairs endocytosis and leads to dopaminergic neurodegeneration.

Authors:  Qinfang Liu; Judith Bautista-Gomez; Daniel A Higgins; Jianzhong Yu; Yulan Xiong
Journal:  Sci Signal       Date:  2021-07-27       Impact factor: 8.192

9.  Pathway-specific dysregulation of striatal excitatory synapses by LRRK2 mutations.

Authors:  Chuyu Chen; Giulia Soto; Vasin Dumrongprechachan; Nicholas Bannon; Shuo Kang; Yevgenia Kozorovitskiy; Loukia Parisiadou
Journal:  Elife       Date:  2020-10-02       Impact factor: 8.140

10.  LRRK2 mediates tubulation and vesicle sorting from lysosomes.

Authors:  Luis Bonet-Ponce; Alexandra Beilina; Chad D Williamson; Eric Lindberg; Jillian H Kluss; Sara Saez-Atienzar; Natalie Landeck; Ravindran Kumaran; Adamantios Mamais; Christopher K E Bleck; Yan Li; Mark R Cookson
Journal:  Sci Adv       Date:  2020-11-11       Impact factor: 14.136
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