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Literature DB >> 3105438

In vitro susceptibility of gram-positive cocci to paldimycin.

D J Pohlod, L D Saravolatz, M M Somerville.

Abstract

Paldimycin (U-70138F) is a new antimicrobial agent with activity against gram-positive cocci. Clinical isolates of staphylococci and streptococci were tested. MICs were higher in Mueller-Hinton broth than in nutrient broth. Change in pH had minimal effect on the MICs in either broth. When inoculum size was varied, an inoculum effect was observed. The gram-positive cocci tested were generally more susceptible to paldimycin than to vancomycin.

Entities: Chemical

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Year: 1987 PMID： 3105438 PMCID： PMC174662 DOI： 10.1128/AAC.31.1.104

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

7 in total

1. Influence of inoculum size on comparative susceptibilities of penicillinase-positive and -negative Neisseria gonorrhoeae to 31 antimicrobial agents.

Authors: W H Hall; B J Opfer
Journal: Antimicrob Agents Chemother Date: 1984-08 Impact factor: 5.191

2. New recommendations for disk diffusion antimicrobial susceptibility tests for methicillin-resistant (heteroresistant) staphylococci.

Authors: L K McDougal; C Thornsberry
Journal: J Clin Microbiol Date: 1984-04 Impact factor: 5.948

3. Effects of changes in pH, medium, and inoculum size on the in vitro activity of amifloxacin against urinary isolates of Staphylococcus saprophyticus and Escherichia coli.

Authors: A Iravani; G S Welty; B R Newton; G A Richard
Journal: Antimicrob Agents Chemother Date: 1985-04 Impact factor: 5.191

2 in total

1. In vitro evaluation of the new paulomycin antibiotic paldimycin.

Authors: G M Eliopoulos; E Reiszner; R C Moellering
Journal: Eur J Clin Microbiol Date: 1987-06 Impact factor: 3.267

2. In vitro activities of daptomycin (LY146032) and paldimycin (U-70,138F) against anaerobic gram-positive bacteria.

Authors: A W Chow; N Cheng
Journal: Antimicrob Agents Chemother Date: 1988-05 Impact factor: 5.191

2 in total

In vitro susceptibility of gram-positive cocci to paldimycin.

1. Influence of inoculum size on comparative susceptibilities of penicillinase-positive and -negative Neisseria gonorrhoeae to 31 antimicrobial agents.

2. New recommendations for disk diffusion antimicrobial susceptibility tests for methicillin-resistant (heteroresistant) staphylococci.

3. Effects of changes in pH, medium, and inoculum size on the in vitro activity of amifloxacin against urinary isolates of Staphylococcus saprophyticus and Escherichia coli.

4. Inoculum effect of new beta-lactam antibiotics on Pseudomonas aeruginosa.

5. Method of reliable determination of minimal lethal antibiotic concentrations.

6. Inoculum effect of beta-lactam antibiotics on Enterobacteriaceae.

7. Paulomycins A and B. Isolation and characterization.

1. In vitro evaluation of the new paulomycin antibiotic paldimycin.

2. In vitro activities of daptomycin (LY146032) and paldimycin (U-70,138F) against anaerobic gram-positive bacteria.