Dietrich Beitzke1, Sazan Rasul2, Martin Lyngby Lassen3, Verena Pichler2, Daniela Senn2, Marie Elisabeth Stelzmüller4, Richard Nolz1, Christian Loewe1, Marcus Hacker5. 1. Department of Biomedical Imaging and Image-Guided Therapy, Division of Cardiovascular and Interventional Radiology, Medical University of Vienna, Vienna, Austria. 2. Department of Biomedical Imaging and Image-Guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Waehringer Gürtel 18-20, 1090 Vienna, Austria. 3. QIMP Group, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria. 4. Department of Surgery, Division of Cardiac Surgery, Medical University of Vienna, Vienna, Austria. 5. Department of Biomedical Imaging and Image-Guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Waehringer Gürtel 18-20, 1090 Vienna, Austria. Electronic address: marcus.hacker@meduniwien.ac.at.
Abstract
RATIONALE AND OBJECTIVES: Hybrid positron emission tomography-magnetic resonance (PET-MR) is a novel imaging technology that enables a comprehensive assessment of myocardial viability. The aim of this study was to intra-individually compare simultaneously acquired viability parameters from MRI and PET to determine complementary and redundant information. MATERIALS AND METHODS: Thirty-nine patients with ischemic heart disease (IHD) underwent cardiac PET-MR for myocardial viability assessment. Cardiac magnetic resonance (CMR), including late gadolinium enhancement (LGE), and PET, including a dynamic dual-tracer acquisition of [13N]ammonia ([13N]NH3)/[18F]fluorodeoxyglucose ([18F]FDG), were performed simultaneously. Allocation, extent, and transmural degree of left ventricular (LV) scars were measured from LGE. Perfusion, viability, and hibernation were assessed by PET. RESULTS: A comparison of scar location revealed six more areas of infarction on MR than on PET. Mean LV scarring by CMR was 14% (range, 2% to 42%) and 14% (range, 1% to 46%) by PET (CMR vs. PET: p = 0.9). An intra-individual comparison of scarring showed a good inter-method correlation (r = 0.7), which was also evident in the subgroup with low ejection fraction (EF) (r = 0.6). Hibernation and transmural degree of scars showed a moderate to weak correlation (r = 0.4), which was even worse in the low EF group (r = 0.1). CONCLUSIONS: In patients with IHD, there was a good correlation between PET and CMR for the LV scar extent using hybrid cardiac PET-MR. The degree of transmural scarring by CMR showed no correlation to PET hibernation. Therefore, cardiac PET-MR might be a suitable tool for a comprehensive assessment of myocardial viability if used to predict response to cardiac reperfusion strategies.
RATIONALE AND OBJECTIVES: Hybrid positron emission tomography-magnetic resonance (PET-MR) is a novel imaging technology that enables a comprehensive assessment of myocardial viability. The aim of this study was to intra-individually compare simultaneously acquired viability parameters from MRI and PET to determine complementary and redundant information. MATERIALS AND METHODS: Thirty-nine patients with ischemic heart disease (IHD) underwent cardiac PET-MR for myocardial viability assessment. Cardiac magnetic resonance (CMR), including late gadolinium enhancement (LGE), and PET, including a dynamic dual-tracer acquisition of [13N]ammonia ([13N]NH3)/[18F]fluorodeoxyglucose ([18F]FDG), were performed simultaneously. Allocation, extent, and transmural degree of left ventricular (LV) scars were measured from LGE. Perfusion, viability, and hibernation were assessed by PET. RESULTS: A comparison of scar location revealed six more areas of infarction on MR than on PET. Mean LV scarring by CMR was 14% (range, 2% to 42%) and 14% (range, 1% to 46%) by PET (CMR vs. PET: p = 0.9). An intra-individual comparison of scarring showed a good inter-method correlation (r = 0.7), which was also evident in the subgroup with low ejection fraction (EF) (r = 0.6). Hibernation and transmural degree of scars showed a moderate to weak correlation (r = 0.4), which was even worse in the low EF group (r = 0.1). CONCLUSIONS: In patients with IHD, there was a good correlation between PET and CMR for the LV scar extent using hybrid cardiac PET-MR. The degree of transmural scarring by CMR showed no correlation to PET hibernation. Therefore, cardiac PET-MR might be a suitable tool for a comprehensive assessment of myocardial viability if used to predict response to cardiac reperfusion strategies.
Authors: Sazan Rasul; Dietrich Beitzke; Tim Wollenweber; Ivo Rausch; Martin Lyngby Lassen; Marie Elisabeth Stelzmüller; Markus Mitterhauser; Verena Pichler; Thomas Beyer; Christian Loewe; Marcus Hacker Journal: J Nucl Cardiol Date: 2020-10-22 Impact factor: 3.872
Authors: Terrence D Ruddy; Mouaz Al-Mallah; James A Arrighi; John P Bois; David A Bluemke; Marcelo F Di Carli; Vasken Dilsizian; Robert J Gropler; Hossein Jadvar; Saurabh Malhotra; Matthier Pelletier-Galarneau; Thomas H Schindler; Pamela K Woodard; Panithaya Chareonthaitawee Journal: Circ Cardiovasc Imaging Date: 2022-08-03 Impact factor: 8.589
Authors: Terrence D Ruddy; Mouaz Al-Mallah; James A Arrighi; John P Bois; David A Bluemke; Marcelo F Di Carli; Vasken Dilsizian; Robert J Gropler; Hossein Jadvar; Saurabh Malhotra; Matthieu Pelletier-Galarneau; Thomas H Schindler; Pamela K Woodard; Panithaya Chareonthaitawee Journal: J Cardiovasc Magn Reson Date: 2022-07-19 Impact factor: 6.903