Apichart So-Ngern1, Naricha Chirakalwasan2,3, Sunee Saetung4, Suwannee Chanprasertyothin5, Ammarin Thakkinstian6, Sirimon Reutrakul4,7. 1. Division of Sleep Medicine, Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. 2. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. 3. Excellence Center for Sleep Disorders, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand. 4. Division of Endocrinology and Metabolism, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. 5. Research Center, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. 6. Section for Clinical Epidemiology and Biostatistics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. 7. Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois.
Abstract
STUDY OBJECTIVES:Sleep deprivation is known to be associated with insulin resistance and diabetes risk. This study investigated whether 2-week sleep extension in chronically sleep-deprived individuals would improve glucose metabolism. METHODS: A crossover study was conducted in volunteers without diabetes who reported sleeping ≤ 6 h/night. They were randomized to maintain their habitual sleep or extend sleep time for 2 weeks, then crossed over after a washout period. Sleep was monitored by actigraphy. Oral glucose tolerance tests (75 g) with insulin levels was performed at the end of each period. Mixed-effect linear regression analysis, adjusting for sequence and period effects, was applied. RESULTS: A total of 21 participants (19 females) with mean (standard deviation) age of 33.1 (6.1) years completed the protocol. Mean sleepduration during habitual sleep was 318.7 (44.3) minutes and the participants extended their sleep by 36.0 (45.2) minutes during sleep extension. The average washout period was 21 (11) days. There were no significant effects of sleep extension on any metabolic parameters. The per-protocol analysis included eight participants who could sleep more than 6 hours during sleep extension (mean sleep duration 396 [25] minutes, extended by 60.1 [28.5] minutes). Among these individuals, sleep extension improved Homeostatic Model Assessment of Insulin Resistance (adjusted mean difference -0.50 [95% confidence interval [CI] -0.89, -0.11, P = .013]), early insulin secretion (insulinogenic index; mean difference 0.39 [95% CI 0.15, 0.63, P = .001]), and β-cell function (disposition index, mean difference 1.07 [95% CI 0.17, 1.97, P = .02]). CONCLUSIONS:Sleep extension in chronically sleep-deprived individuals improved glucose metabolism in only those who could objectively extend their sleep to more than 6 h/night. Our findings suggest that a critical amount of sleep is needed to benefit metabolic outcomes.
RCT Entities:
STUDY OBJECTIVES: Sleep deprivation is known to be associated with insulin resistance and diabetes risk. This study investigated whether 2-week sleep extension in chronically sleep-deprived individuals would improve glucose metabolism. METHODS: A crossover study was conducted in volunteers without diabetes who reported sleeping ≤ 6 h/night. They were randomized to maintain their habitual sleep or extend sleep time for 2 weeks, then crossed over after a washout period. Sleep was monitored by actigraphy. Oral glucose tolerance tests (75 g) with insulin levels was performed at the end of each period. Mixed-effect linear regression analysis, adjusting for sequence and period effects, was applied. RESULTS: A total of 21 participants (19 females) with mean (standard deviation) age of 33.1 (6.1) years completed the protocol. Mean sleep duration during habitual sleep was 318.7 (44.3) minutes and the participants extended their sleep by 36.0 (45.2) minutes during sleep extension. The average washout period was 21 (11) days. There were no significant effects of sleep extension on any metabolic parameters. The per-protocol analysis included eight participants who could sleep more than 6 hours during sleep extension (mean sleep duration 396 [25] minutes, extended by 60.1 [28.5] minutes). Among these individuals, sleep extension improved Homeostatic Model Assessment of Insulin Resistance (adjusted mean difference -0.50 [95% confidence interval [CI] -0.89, -0.11, P = .013]), early insulin secretion (insulinogenic index; mean difference 0.39 [95% CI 0.15, 0.63, P = .001]), and β-cell function (disposition index, mean difference 1.07 [95% CI 0.17, 1.97, P = .02]). CONCLUSIONS: Sleep extension in chronically sleep-deprived individuals improved glucose metabolism in only those who could objectively extend their sleep to more than 6 h/night. Our findings suggest that a critical amount of sleep is needed to benefit metabolic outcomes.
Authors: Frank A J L Scheer; Michael F Hilton; Christos S Mantzoros; Steven A Shea Journal: Proc Natl Acad Sci U S A Date: 2009-03-02 Impact factor: 11.205
Authors: M Thomas; H Sing; G Belenky; H Holcomb; H Mayberg; R Dannals; H Wagner; D Thorne; K Popp; L Rowland; A Welsh; S Balwinski; D Redmond Journal: J Sleep Res Date: 2000-12 Impact factor: 3.981
Authors: Ram Weiss; Anna M Cali; James Dziura; Tania S Burgert; William V Tamborlane; Sonia Caprio Journal: Diabetes Care Date: 2007-05-02 Impact factor: 19.112
Authors: A N Vgontzas; E Zoumakis; E O Bixler; H-M Lin; H Follett; A Kales; G P Chrousos Journal: J Clin Endocrinol Metab Date: 2004-05 Impact factor: 5.958
Authors: Wessel M A van Leeuwen; Maili Lehto; Piia Karisola; Harri Lindholm; Ritva Luukkonen; Mikael Sallinen; Mikko Härmä; Tarja Porkka-Heiskanen; Harri Alenius Journal: PLoS One Date: 2009-02-25 Impact factor: 3.240
Authors: Dale Elizabeth Rae; Lara Ruth Dugas; Laura Catherine Roden; Estelle Vicki Lambert; Pascal Bovet; Jacob Plange-Rhule; Terrence Forrester; Walter Riesen; Wolfgang Korte; Stephanie J Crowley; Sirimon Reutrakul; Amy Luke Journal: Sleep Health Date: 2020-04-19
Authors: Dana Withrow; Samuel J Bowers; Christopher M Depner; Antonio González; Amy C Reynolds; Kenneth P Wright Journal: Curr Opin Endocr Metab Res Date: 2020-11-28
Authors: Sirimon Reutrakul; Pamela Martyn-Nemeth; Lauretta Quinn; Brett Rydzon; Medha Priyadarshini; Kirstie K Danielson; Kelly G Baron; Jennifer Duffecy Journal: Pilot Feasibility Stud Date: 2022-06-04
Authors: Na Fei; Candice Choo-Kang; Sirimon Reutrakul; Stephanie J Crowley; Dale Rae; Kweku Bedu-Addo; Jacob Plange-Rhule; Terrence E Forrester; Estelle V Lambert; Pascal Bovet; Walter Riesen; Wolfgang Korte; Amy Luke; Brian T Layden; Jack A Gilbert; Lara R Dugas Journal: PLoS One Date: 2021-09-08 Impact factor: 3.240