Literature DB >> 31051132

Lessons from London and Berlin: Designing A Scalable Gene Therapy Approach for HIV Cure.

Christopher W Peterson1, Hans-Peter Kiem2.   

Abstract

Recently in Nature, Gupta et al. (2019) reported that a second patient has achieved HIV-1 remission/functional cure after allogeneic hematopoietic stem cell transplantation from a donor carrying a mutation in the CCR5 coreceptor. We highlight both patients' treatments and summarize efforts to develop a broader, more patient-friendly approach.
Copyright © 2019 Elsevier Inc. All rights reserved.

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Year:  2019        PMID： 31051132     DOI： 10.1016/j.stem.2019.04.010

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   25.269


  12 in total

Review 1.  Deciphering DNA Methylation in HIV Infection.

Authors:  Thilona Arumugam; Upasana Ramphal; Theolan Adimulam; Romona Chinniah; Veron Ramsuran
Journal:  Front Immunol       Date:  2021-12-02       Impact factor: 7.561

2.  Efficient polymer nanoparticle-mediated delivery of gene editing reagents into human hematopoietic stem and progenitor cells.

Authors:  Rkia El-Kharrag; Kurt E Berckmueller; Ravishankar Madhu; Margaret Cui; Gabriela Campoy; Heather M Mack; Carl B Wolf; Anai M Perez; Olivier Humbert; Hans-Peter Kiem; Stefan Radtke
Journal:  Mol Ther       Date:  2022-02-28       Impact factor: 12.910

Review 3.  Genome editing in large animal models.

Authors:  Lucy H Maynard; Olivier Humbert; Christopher W Peterson; Hans-Peter Kiem
Journal:  Mol Ther       Date:  2021-10-01       Impact factor: 11.454

4.  A Trispecific Anti-HIV Chimeric Antigen Receptor Containing the CCR5 N-Terminal Region.

Authors:  Agnes Hajduczki; David T Danielson; David S Elias; Virgilio Bundoc; Aaron W Scanlan; Edward A Berger
Journal:  Front Cell Infect Microbiol       Date:  2020-05-25       Impact factor: 5.293

5.  Isolation of a Highly Purified HSC-enriched CD34+CD90+CD45RA- Cell Subset for Allogeneic Transplantation in the Nonhuman Primate Large-animal Model.

Authors:  Stefan Radtke; Lucrezia Colonna; Anai M Perez; Michelle Hoffman; Leslie S Kean; Hans-Peter Kiem
Journal:  Transplant Direct       Date:  2020-07-15

6.  Thresholds for post-rebound SHIV control after CCR5 gene-edited autologous hematopoietic cell transplantation.

Authors:  E Fabian Cardozo-Ojeda; Elizabeth R Duke; Christopher W Peterson; Daniel B Reeves; Bryan T Mayer; Hans-Peter Kiem; Joshua T Schiffer
Journal:  Elife       Date:  2021-01-12       Impact factor: 8.713

7.  Stem cell-derived CAR T cells traffic to HIV reservoirs in macaques.

Authors:  Isaac M Barber-Axthelm; Valerie Barber-Axthelm; Kai Yin Sze; Anjie Zhen; Gajendra W Suryawanshi; Irvin Sy Chen; Jerome A Zack; Scott G Kitchen; Hans-Peter Kiem; Christopher W Peterson
Journal:  JCI Insight       Date:  2021-01-11

8.  Cell membrane-anchored anti-HIV single-chain antibodies and bifunctional inhibitors targeting the gp41 fusion protein: new strategies for HIV gene therapy.

Authors:  Yue Chen; Hongliang Jin; Xiaoran Tang; Li Li; Xiuzhu Geng; Yuanmei Zhu; Huihui Chong; Yuxian He
Journal:  Emerg Microbes Infect       Date:  2022-12       Impact factor: 7.163

Review 9.  Editing out HIV: application of gene editing technology to achieve functional cure.

Authors:  Jingna Xun; Xinyu Zhang; Shuyan Guo; Hongzhou Lu; Jun Chen
Journal:  Retrovirology       Date:  2021-12-18       Impact factor: 4.602

Review 10.  Lessons Learned From Failures and Success Stories of HIV Breakthroughs: Are We Getting Closer to an HIV Cure?

Authors:  V Kalidasan; Kumitaa Theva Das
Journal:  Front Microbiol       Date:  2020-01-31       Impact factor: 5.640
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