Literature DB >> 31049834

miR-30a reverses TGF-β2-induced migration and EMT in posterior capsular opacification by targeting Smad2.

Hua Li1, Hui Song1, Xiaoyong Yuan1, Jun Li1, Hua Tang2.   

Abstract

Posterior capsular opacification (PCO) leads to secondary vision loss following cataract surgery. TGF-β2 and miRNA play important roles in PCO. The aim of this study was to investigate the reciprocal crosstalk between miR-30a and TGF-β2/Smad2 during PCO progression. The expressions of and relationship between miR-30a and Smad2 were detected by RT-qPCR. Migration and epithelial-mesenchymal transition (EMT) were used to evaluate the functions of miR-30a and TGF-β2/Smad2. We found that miR-30a was downregulated by TGF-β2 and that it suppressed migration and EMT induced by TGF-β2. Moreover, we identified Smad2 as a direct target of miR-30a, suggesting that miR-30a may function partly through regulating Smad2. Altogether, we verified the function of and crosstalk between miR-30a and TGF-β2. We also provide evidence that miR-30a may serve as a potential candidate for PCO treatment.

Entities:  

Keywords:  Posterior capsular opacification; Smad2; TGF-β2; miR-30a

Mesh：

Substances：

Year:  2019        PMID： 31049834     DOI： 10.1007/s11033-019-04833-4

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  21 in total

1.  Comparative effects of TGF-β2/Smad2 and TGF-β2/Smad3 signaling pathways on proliferation, migration, and extracellular matrix production in a human lens cell line.

Authors:  Jun Li; Xin Tang; Xia Chen
Journal:  Exp Eye Res       Date:  2011-01-27       Impact factor: 3.467

2.  MiRNA-26b inhibits the proliferation, migration, and epithelial-mesenchymal transition of lens epithelial cells.

Authors:  Ning Dong; Bing Xu; Silvia R Benya; Xin Tang
Journal:  Mol Cell Biochem       Date:  2014-07-26       Impact factor: 3.396

3.  MMP2 activity is critical for TGFβ2-induced matrix contraction--implications for fibrosis.

Authors:  Julie A Eldred; Lisa M Hodgkinson; Lucy J Dawes; John R Reddan; Dylan R Edwards; I Michael Wormstone
Journal:  Invest Ophthalmol Vis Sci       Date:  2012-06-26       Impact factor: 4.799

Review 4.  The lens as a model for fibrotic disease.

Authors:  J A Eldred; L J Dawes; I M Wormstone
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2011-04-27       Impact factor: 6.237

5.  MicroRNA-204-5p regulates epithelial-to-mesenchymal transition during human posterior capsule opacification by targeting SMAD4.

Authors:  Ye Wang; Wenfeng Li; Xinjie Zang; Nan Chen; Ting Liu; Panagiotis A Tsonis; Yusen Huang
Journal:  Invest Ophthalmol Vis Sci       Date:  2013-01-14       Impact factor: 4.799

6.  Characterisation of TGF-beta2 signalling and function in a human lens cell line.

Authors:  I M Wormstone; S Tamiya; J A Eldred; K Lazaridis; A Chantry; J R Reddan; I Anderson; G Duncan
Journal:  Exp Eye Res       Date:  2004-03       Impact factor: 3.467

7.  TGF-beta2-induced matrix modification and cell transdifferentiation in the human lens capsular bag.

Authors:  I Michael Wormstone; Shigeo Tamiya; Ian Anderson; George Duncan
Journal:  Invest Ophthalmol Vis Sci       Date:  2002-07       Impact factor: 4.799

8.  Implication of Smad2 and Smad3 in transforming growth factor-β-induced posterior capsular opacification of human lens epithelial cells.

Authors:  Hua Li; Xiaoyong Yuan; Jun Li; Xin Tang
Journal:  Curr Eye Res       Date:  2014-06-09       Impact factor: 2.424

Review 9.  Smad-dependent and Smad-independent pathways in TGF-beta family signalling.

Authors:  Rik Derynck; Ying E Zhang
Journal:  Nature       Date:  2003-10-09       Impact factor: 49.962

10.  Downregulation of transforming growth factor-β type II receptor prohibit epithelial-to-mesenchymal transition in lens epithelium.

Authors:  Danying Zheng; Tingting Song; Xueying Zhongliu; Mingxing Wu; Jingli Liang; Yizhi Liu
Journal:  Mol Vis       Date:  2012-05-11       Impact factor: 2.367
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  5 in total

1.  Vision function of pseudophakic eyes with posterior capsular opacification under different speed and spatial frequency.

Authors:  Ziyuan Liu; Zhiqiang Hou; Shan Ge; Honglei Pang; Wei Wang
Journal:  Int Ophthalmol       Date:  2020-10-08       Impact factor: 2.031

2.  MicroRNA Profiling Reveals an Abundant miR-200a-3p Promotes Skeletal Muscle Satellite Cell Development by Targeting TGF-β2 and Regulating the TGF‑β2/SMAD Signaling Pathway.

Authors:  Huadong Yin; Haorong He; Xiaoxu Shen; Shuyue Tang; Jing Zhao; Xinao Cao; Shunshun Han; Can Cui; Yuqi Chen; Yuanhang Wei; Yan Wang; Diyan Li; Qing Zhu
Journal:  Int J Mol Sci       Date:  2020-05-05       Impact factor: 5.923

Review 3.  Research Progress of Drug Prophylaxis for Lens Capsule Opacification after Cataract Surgery.

Authors:  Rong-Pei Zhang; Zheng-Gao Xie
Journal:  J Ophthalmol       Date:  2020-07-04       Impact factor: 1.909

4.  lncRNA XIST knockdown suppresses cell proliferation and promotes apoptosis in diabetic cataracts through the miR‑34a/SMAD2 axis.

Authors:  Chao Wang; Ruiling Zhao; Suhong Zhang
Journal:  Mol Med Rep       Date:  2021-11-09       Impact factor: 2.952

5.  IGF-1 Promotes Epithelial-Mesenchymal Transition of Lens Epithelial Cells That Is Conferred by miR-3666 Loss.

Authors:  Chao Wang; Baowen Zhao; Jiahui Fang; Zhan Shi
Journal:  Contrast Media Mol Imaging       Date:  2022-07-14       Impact factor: 3.009
  5 in total

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