| Literature DB >> 3104951 |
Abstract
Non-deprived rats were allowed 1-h access to a range of saccharin solutions from 0.001 to 0.1 M Na saccharin. Compared to a group of rats drinking tap water, the rats drinking the saccharin solutions ingested a great deal more fluid, with as much as 24-30 ml consumed of the 0.01 M concentration, compared to 3-5 ml in controls. Fluoxetine (IP) decreased this palatability-induced excessive consumption in a dose-related manner. Effects of 10 mg/kg fluoxetine were apparent for 48 h after injection. This effect on palatability-induced ingestion may relate to previously reported effects of fluoxetine on food consumption.Entities:
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Year: 1987 PMID: 3104951 DOI: 10.1007/bf00518178
Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN: 0033-3158 Impact factor: 4.530