Andrei Ionut Cucu1, Claudia Florida Costea2, Antonio Perciaccante3, Alexandru Carauleanu4, Serban Turliuc5, Bogdan Costachescu6, Ion Poeata6, Mihaela Dana Turliuc6. 1. Neurosurgery Clinic, "Prof. Dr. N. Oblu" Emergency Clinical Hospital, Iasi, Romania. 2. Department of Ophthalmology, "Grigore. T. Popa" University of Medicine and Pharmacy, Iasi, Romania. Electronic address: costea10@yahoo.com. 3. Department of Medicine, "San Giovanni di Dio" Hospital, Gorizia, Italy. 4. Department of Obstetrics and Gynecology, "Grigore. T. Popa" University of Medicine and Pharmacy, Iasi, Romania. 5. Department of Psychiatry, "Grigore. T. Popa" University of Medicine and Pharmacy, Iasi, Romania. 6. Department of Neurosurgery, "Grigore. T. Popa" University of Medicine and Pharmacy, Iasi, Romania.
Abstract
BACKGROUND: Intracranial meningiomas are brain tumors that have probably been known the longest, largely because of the occasional production of grotesque cranial deformities that have attracted the attention and interest of humankind. Because of the tendency of some intracranial meningiomas to cause skull deformation and thickening, these tumors have given rise to various speculations and theories related to their origin, starting in prehistoric times up to the present. METHODS: From the Steinheim skull and "pharaonic meningiomas" to the first meningioma monograph and the first explanations of Harvey Cushing regarding the mechanism of hyperostosis, this review aims to weave again the story of Arachne. We identify the main contributors who have tried to understand and explain the tendency of some of these tumors to cause hyperostosis or other skull bone involvements. CONCLUSIONS: The contribution of neurosurgeons or pathologists over the centuries is of undeniable importance and is the basis for understanding future molecular mechanisms.
BACKGROUND:Intracranial meningiomas are brain tumors that have probably been known the longest, largely because of the occasional production of grotesque cranial deformities that have attracted the attention and interest of humankind. Because of the tendency of some intracranial meningiomas to cause skull deformation and thickening, these tumors have given rise to various speculations and theories related to their origin, starting in prehistoric times up to the present. METHODS: From the Steinheim skull and "pharaonic meningiomas" to the first meningioma monograph and the first explanations of Harvey Cushing regarding the mechanism of hyperostosis, this review aims to weave again the story of Arachne. We identify the main contributors who have tried to understand and explain the tendency of some of these tumors to cause hyperostosis or other skull bone involvements. CONCLUSIONS: The contribution of neurosurgeons or pathologists over the centuries is of undeniable importance and is the basis for understanding future molecular mechanisms.
Authors: A I Cucu; S Turliuc; C F Costea; A Perciaccante; R Bianucci; S Donell; D V Scripcariu; M D Turliuc Journal: Neurosurg Rev Date: 2021-02-12 Impact factor: 3.042