| Literature DB >> 31044595 |
Shuai Liu1,2, Yuping Zhao2, Christian Heering3, Christoph Janiak3, Werner E G Müller4, Sergi Hervé Akoné1,5, Zhen Liu1, Peter Proksch1.
Abstract
Ten new sesquiterpenoid derivatives, rhinomilisins A-J (1-10), along with six known analogues (11-16), were isolated from the mangrove-derived endophytic fungus Rhinocladiella similis. The structures of the new compounds were elucidated by their NMR and MS data, while the absolute configuration of 3 and 6 was determined by X-ray crystallographic analysis and Mosher's method, respectively. All isolated compounds (1-16) were evaluated for their cytotoxicity against the mouse lymphoma cell line L5178Y, and compounds 1, 7, and 15 showed moderate activity with IC50 values of 5.0, 8.7, and 24.4 μM, respectively.Entities:
Year: 2019 PMID: 31044595 DOI: 10.1021/acs.jnatprod.8b00938
Source DB: PubMed Journal: J Nat Prod ISSN: 0163-3864 Impact factor: 4.050