Literature DB >> 31043911

A Biomedical Approach Via Telemedicine in the Treatment of a Child With Sensory Processing Disorder Using Diet and High-dose Biotin Intervention: A Case Report.

Gail Clayton1, Heather A Carrera1, Edward R Martin1, Demetrice Morrison1, Abubakar A Bawazir1.   

Abstract

BACKGROUND: We present the case of a 6-y-old boy who was diagnosed with sensory processing disorder with developmental language and learning delay. He was treated successfully with diet and high-dose biotin along with other nutrient support that resulted in resolution of abnormal sensory behaviors and improvement in language and learning. CASE/INTERVENTION: The child was diagnosed with a presumed biotin deficiency from organic acids testing which revealed markers that reflected biotin deficiency despite supplementation with 300 mcg daily (AI = 12 mcg/d). Stool markers were also noted for low beneficial biotin producing microbiota. In the course of several months of high-dose biotin supplementation with herbal treatment for dysbiosis, he was able to subsequently transition from special needs classes requiring sensory support into mainstream classes as a neurotypical child with age appropriate language and learning skills and resolution of abnormal sensory behaviors.
CONCLUSION: This case illustrates the importance of using functional nutrition labs to rule out nutrient imbalances that could be a cause of improper signaling in the brain, which can translate into delayed language, learning, and behavior disorders. Organic acids may reveal a much higher level of need of nutrients, especially when polymorphisms of enzymes are present that may be responsive, as this case demonstrates, to targeted high-dose nutrient therapy.

Entities:  

Year:  2018        PMID: 31043911      PMCID: PMC6469460     

Source DB:  PubMed          Journal:  Integr Med (Encinitas)        ISSN: 1546-993X


  6 in total

Review 1.  New Assessments and Treatments in ASD.

Authors:  Roula N Choueiri; Andrew W Zimmerman
Journal:  Curr Treat Options Neurol       Date:  2017-02       Impact factor: 3.598

2.  CARE guidelines for case reports: explanation and elaboration document.

Authors:  David S Riley; Melissa S Barber; Gunver S Kienle; Jeffrey K Aronson; Tido von Schoen-Angerer; Peter Tugwell; Helmut Kiene; Mark Helfand; Douglas G Altman; Harold Sox; Paul G Werthmann; David Moher; Richard A Rison; Larissa Shamseer; Christian A Koch; Gordon H Sun; Patrick Hanaway; Nancy L Sudak; Marietta Kaszkin-Bettag; James E Carpenter; Joel J Gagnier
Journal:  J Clin Epidemiol       Date:  2017-05-18       Impact factor: 6.437

Review 3.  Biotin--a regulator of gene expression.

Authors:  Krishnamurti Dakshinamurti
Journal:  J Nutr Biochem       Date:  2005-07       Impact factor: 6.048

Review 4.  Branched-chain amino acids and brain function.

Authors:  John D Fernstrom
Journal:  J Nutr       Date:  2005-06       Impact factor: 4.798

Review 5.  Autism spectrum disorder in the scope of tactile processing.

Authors:  Mark Mikkelsen; Ericka L Wodka; Stewart H Mostofsky; Nicolaas A J Puts
Journal:  Dev Cogn Neurosci       Date:  2016-12-23       Impact factor: 6.464

6.  Holocarboxylase synthetase deficiency pre and post newborn screening.

Authors:  Taraka R Donti; Patrick R Blackburn; Paldeep S Atwal
Journal:  Mol Genet Metab Rep       Date:  2016-04-06
  6 in total

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