Fei Jiang1, Fanglan Hong1, Muhammad Waseem Shah2, Xiaobing Shen3. 1. Key Laboratory of Environmental Medical Engineering and Education Ministry, School of Public Health, Southeast University, Nanjing, 210000, China; Department of Preventive Medicine, School of Public Health, Southeast University, Nanjing, 210000, China. 2. Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, 210000, China. 3. Key Laboratory of Environmental Medical Engineering and Education Ministry, School of Public Health, Southeast University, Nanjing, 210000, China; Department of Preventive Medicine, School of Public Health, Southeast University, Nanjing, 210000, China. Electronic address: xb.shen@seu.edu.cn.
Abstract
PURPOSE: Gastric cancer is a malignant tumor in the world and circRNA has a close connection with it. However, the effects of circRNA on gastric cancer is still not clear. METHODS: A comprehensive search of PubMed, Web of Science and Embase for published experimental studies about circRNA from 2013 to June 2018 was conducted with two investigators. Diagnostic OR (DOR) was calculated to evaluate the diagnostic efficacy by STATA 12.0. RESULTS: Total 11 studies were found, including 12 kinds of circRNAs, 11 in tissues, 5 in plasma, and all down regulated. The combined DOR and AUC (Area Under the Curve of Receiver Operating Characteristic) with their 95%CI were 8.778 [6.108, 12.614] and 0.81 [0.78, 0.84] respectively, indicating that circRNAs can reflect gastric cancer as well. Subgroup analysis revealed that circRNAs in plasma were higher than tissues as well as in subgroup with different sample sizes. We speculated that the heterogeneity of the literatures was mainly due to the different backgrounds of gastric cancer and the differences in experimental design and operation process. And the Deeks' funnel map revealed there was no obvious public biasness in the literature. CONCLUSION: CircRNAs have high sensitivity and specificity in the diagnosis of gastric cancer, and it may become an auxiliary diagnostic biomarker of gastric cancer.
PURPOSE:Gastric cancer is a malignant tumor in the world and circRNA has a close connection with it. However, the effects of circRNA on gastric cancer is still not clear. METHODS: A comprehensive search of PubMed, Web of Science and Embase for published experimental studies about circRNA from 2013 to June 2018 was conducted with two investigators. Diagnostic OR (DOR) was calculated to evaluate the diagnostic efficacy by STATA 12.0. RESULTS: Total 11 studies were found, including 12 kinds of circRNAs, 11 in tissues, 5 in plasma, and all down regulated. The combined DOR and AUC (Area Under the Curve of Receiver Operating Characteristic) with their 95%CI were 8.778 [6.108, 12.614] and 0.81 [0.78, 0.84] respectively, indicating that circRNAs can reflect gastric cancer as well. Subgroup analysis revealed that circRNAs in plasma were higher than tissues as well as in subgroup with different sample sizes. We speculated that the heterogeneity of the literatures was mainly due to the different backgrounds of gastric cancer and the differences in experimental design and operation process. And the Deeks' funnel map revealed there was no obvious public biasness in the literature. CONCLUSION: CircRNAs have high sensitivity and specificity in the diagnosis of gastric cancer, and it may become an auxiliary diagnostic biomarker of gastric cancer.
Authors: Karolina Elżbieta Kaczor-Urbanowicz; Mustafa Saad; Tristan R Grogan; Feng Li; You Jeong Heo; David Elashoff; Robert S Bresalier; David T W Wong; Yong Kim Journal: Cancers (Basel) Date: 2022-07-26 Impact factor: 6.575