| Literature DB >> 31042564 |
Chao Ren1, Xinxin Gu2, Huihua Li3, Shihui Lei4, Zhe Wang5, Jiahui Wang6, Peiyuan Yin7, Caiyi Zhang8, Fen Wang9, Chunfeng Liu10.
Abstract
Dickkopf-1 (DKK1), a secretory glycoprotein discovered for 'inducing generation of head', is an endogenous inhibitor of the canonical Wnt/β-catenin signaling pathway. It was found to be involved in many pathophysiological processes in vivo. Abnormal expression of DKK1 will alter expressions of related proteins and genes not only in canonical Wnt/β-catenin signaling pathway but also in other signaling pathways. Previous studies of DKK1 focused on its function in tumors. In recent years, a large number of studies have shown that it plays an important role in embryonic development, neural regeneration, synaptogenesis and so on. Therefore, its role in neuropsychiatric disorders, such as neurodysplasia, cognitive impairment and emotional disorder, has attracted increasing attention. At present, the role of DKK1 in Alzheimer's disease (AD) is one of the research hot topics. This article reviewed the research progress of its role in AD in order to provide new ideas and directions for further studies on the pathogenesis and treatment of AD.Entities:
Keywords: Alzheimer’s disease; DKK1; Inhibitor; Neural regeneration; Wnt signaling
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Year: 2019 PMID： 31042564 DOI： 10.1016/j.phrs.2019.04.033
Source DB: PubMed Journal: Pharmacol Res ISSN： 1043-6618 Impact factor: 7.658