Literature DB >> 31042071

P2RX7 functions as a putative biomarker of gastric cancer and contributes to worse prognosis.

Wang Lili1, Li Yun2, Wei Tingran3, Wu Xia4, Sun Yanlei5.   

Abstract

IMPACT STATEMENT: The mechanism of gastric cancer is highly complex, accompanied by a variety of genetic abnormalities. It is of great significance to elucidate the pathogenesis of gastric cancer, find its markers and therapeutic targets in the fight against this fatal disease. In this study, we identified P2RX7 as a putative target of gastric cancer, which was overexpressed in gastric cancer tissues and had relationship with worse prognosis. We also elucidated the roles of P2RX7 on the growth and metastasis of gastric cancer cells, and explored the relationship between it and ERK1/2 pathway, Akt pathway, and epithelial-mesenchymal transition. Our findings begin to offer useful insights into the mechanism of gastric cancer progression and provide clues to novel therapy strategies.

Entities:  

Keywords:  P2RX7; gastric cancer; metastasis; proliferation

Mesh：

Substances：

Year:  2019        PMID： 31042071      PMCID： PMC6567584          DOI： 10.1177/1535370219846492

Source DB:  PubMed          Journal:  Exp Biol Med (Maywood)        ISSN： 1535-3699


  26 in total

Review 1.  Pharmacology of cloned P2X receptors.

Authors:  R A North; A Surprenant
Journal:  Annu Rev Pharmacol Toxicol       Date:  2000       Impact factor: 13.820

Review 2.  The aging heart and post-infarction left ventricular remodeling.

Authors:  Henry Shih; Brian Lee; Randall J Lee; Andrew J Boyle
Journal:  J Am Coll Cardiol       Date:  2011-01-04       Impact factor: 24.094

Review 3.  Epidermal growth factor receptor in corneal damage: update and new insights from recent reports.

Authors:  E Bonafonte Márquez; D De Ortueta; S Bonafonte Royo; Pedro A Martínez-Carpio
Journal:  Cutan Ocul Toxicol       Date:  2010-11-24       Impact factor: 1.820

4.  P2X(7) receptor activation enhances SK3 channels- and cystein cathepsin-dependent cancer cells invasiveness.

Authors:  B Jelassi; A Chantôme; F Alcaraz-Pérez; A Baroja-Mazo; M L Cayuela; P Pelegrin; A Surprenant; S Roger
Journal:  Oncogene       Date:  2011-01-17       Impact factor: 9.867

5.  P2X and P2Y purinergic receptors on human intestinal epithelial carcinoma cells: effects of extracellular nucleotides on apoptosis and cell proliferation.

Authors:  Robson Coutinho-Silva; Lynn Stahl; Kwok-Kuen Cheung; Nathalia Enes de Campos; Carolina de Oliveira Souza; David M Ojcius; Geoffrey Burnstock
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2005-01-20       Impact factor: 4.052

6.  Functional decreases in P2X7 receptors are associated with retinoic acid-induced neuronal differentiation of Neuro-2a neuroblastoma cells.

Authors:  Pei-Yu Wu; Yu-Chia Lin; Chia-Ling Chang; Hsing-Tsen Lu; Chia-Hsuan Chin; Tsan-Ting Hsu; Dachen Chu; Synthia H Sun
Journal:  Cell Signal       Date:  2009-06       Impact factor: 4.315

7.  Expression of P2X7 in human hematopoietic cell lines and leukemia patients.

Authors:  Xiu-Jun Zhang; Guo-Guang Zheng; Xiao-Tong Ma; Ying-Hua Yang; Ge Li; Qing Rao; Kun Nie; Ke-Fu Wu
Journal:  Leuk Res       Date:  2004-12       Impact factor: 3.156

8.  P2X(7): a growth-promoting receptor-implications for cancer.

Authors:  Francesco Di Virgilio; Davide Ferrari; Elena Adinolfi
Journal:  Purinergic Signal       Date:  2009-03-04       Impact factor: 3.765

9.  Increased P2X7 receptor expression and function in thyroid papillary cancer: a new potential marker of the disease?

Authors:  Anna Solini; Sabina Cuccato; Davide Ferrari; Eleonora Santini; Sara Gulinelli; Maria Giulia Callegari; Angela Dardano; Pinuccia Faviana; Stephanie Madec; Francesco Di Virgilio; Fabio Monzani
Journal:  Endocrinology       Date:  2007-10-18       Impact factor: 4.736

10.  Characterization of ATP-induced cell death in the GL261 mouse glioma.

Authors:  Alessandra S K Tamajusuku; Emilly S Villodre; Romela Paulus; Robson Coutinho-Silva; Ana M O Battasstini; Márcia R Wink; Guido Lenz
Journal:  J Cell Biochem       Date:  2010-04-01       Impact factor: 4.429
View more
  5 in total

Review 1.  Autocrine and paracrine purinergic signaling in the most lethal types of cancer.

Authors:  M Reyna-Jeldes; M Díaz-Muñoz; J A Madariaga; C Coddou; F G Vázquez-Cuevas
Journal:  Purinergic Signal       Date:  2021-05-12       Impact factor: 3.765

2.  Extracellular ATP Mediates Cancer Cell Migration and Invasion Through Increased Expression of Cyclooxygenase 2.

Authors:  Shilpa Sharma; Harshit Kalra; Ravi Shankar Akundi
Journal:  Front Pharmacol       Date:  2021-01-27       Impact factor: 5.810

3.  Establishment of A Nomogram for Predicting the Prognosis of Soft Tissue Sarcoma Based on Seven Glycolysis-Related Gene Risk Score.

Authors:  Yuhang Liu; Changjiang Liu; Hao Zhang; Xinzeyu Yi; Aixi Yu
Journal:  Front Genet       Date:  2021-12-02       Impact factor: 4.599

Review 4.  Pathophysiological Role of Purinergic P2X Receptors in Digestive System Diseases.

Authors:  Qimin An; Gengyu Yue; Xiaoxu Yang; Jun Lou; Weixi Shan; Jianhong Ding; Zhe Jin; Yanxia Hu; Qian Du; Qiushi Liao; Rui Xie; Jingyu Xu
Journal:  Front Physiol       Date:  2021-12-24       Impact factor: 4.566

5.  A loss-of-function polymorphism in ATG16L1 compromises therapeutic outcome in head and neck carcinoma patients.

Authors:  Julie Le Naour; Zsofia Sztupinszki; Vincent Carbonnier; Odile Casiraghi; Virginie Marty; Lorenzo Galluzzi; Zoltan Szallasi; Guido Kroemer; Erika Vacchelli
Journal:  Oncoimmunology       Date:  2022-04-17       Impact factor: 7.723
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.