Literature DB >> 31042053

Candesartan in a rat model of testicular toxicity: New insight on its protective mechanism.

Iman O Sherif1, Osama M Sarhan2.   

Abstract

IMPACT STATEMENT: Cisplatin is a commonly used drug in the treatment of solid tumors and its application is associated with testicular toxicity. The effect of candesartan in cisplatin-induced testicular toxicity and its fundamental mechanism of action were investigated. Candesartan had certainly repaired the testicular injury and ameliorated both biochemical and histopathological changes. Candesartan mitigated the gonadotoxicity induced by cisplatin via antioxidative, anti-inflammatory, and antiapoptotic actions.

Entities:  

Keywords:  Cisplatin; apoptosis; candesartan; oxidative stress index; testicular toxicity

Mesh：

Substances：

Year:  2019        PMID： 31042053      PMCID： PMC6545698          DOI： 10.1177/1535370219842149

Source DB:  PubMed          Journal:  Exp Biol Med (Maywood)        ISSN： 1535-3699


  41 in total

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Authors:  M Aldemir; E Okulu; K Kösemehmetoğlu; K Ener; F Topal; O Evirgen; E Gürleyik; A Avcı
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  1 in total

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  1 in total

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