| Literature DB >> 31041687 |
Jinha Yu1, Gyudong Kim1,2, Dnyandev B Jarhad1, Hong-Rae Kim1, Lak Shin Jeong3.
Abstract
Based on the potent anti-HIV activity of L-2',3'-dideoxycytidine (L-ddC), L-2',3'-dideoxy-4'-selenonucleosides (L-4'-Se-ddNs) have been synthesized from natural chiral template, L-glutamic acid, using Pummerer-type condensation as a key step. All synthesized compounds were assayed for anti-HIV-1 activity, but none of them did show any significant antiviral activity up to 100 μM, probably due to conformational differences between L-ddC and L-4'-Se-ddC, induced by the bulky selenium atom, which might play an important role in phosphorylation by cellular kinase.Entities:
Keywords: Antiviral; L-2′,3′-Dideoxy-4′-selenonucleosides; L-4′-Se-ddC; L-Nucleoside; Pummerer-type condensation
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Year: 2019 PMID： 31041687 DOI： 10.1007/s12272-019-01157-6
Source DB: PubMed Journal: Arch Pharm Res ISSN： 0253-6269 Impact factor: 4.946