Taeho Greg Rhee1, Robert A Rosenheck2. 1. Department of Community Medicine and Health Care, School of Medicine, University of Connecticut, Farmington, CT, USA; Department of Psychiatry, School of Medicine, Yale University, New Haven, CT, USA; New England Mental Illness, Research, Education, and Clinical Center (MIRECC), USA; Department of Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA. Electronic address: rhee@uchc.edu. 2. Department of Psychiatry, School of Medicine, Yale University, New Haven, CT, USA; New England Mental Illness, Research, Education, and Clinical Center (MIRECC), USA; Department of Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA.
Abstract
BACKGROUND: To examine the association of current and past Opiate Use Disorder (OUD) with measures of HRQOL and employment in a nationally representative sample of adults. METHODS: The 2012-2013 National Epidemiological Survey on Alcohol and Related Conditions III (NESARC III) surveyed a nationally representative sample of non-institutionalized civilian adults (≥18 years) in the US (n = 36,309 unweighted). Using DSM-5 criteria, adults without history of OUD were compared to those with current and past OUD. Using the SF-12 items, standard measures of the mental and physical component scores of HRQOL and of quality-adjusted life years (QALYs) were constructed. Employment in the past year (yes/no) was also assessed. Multivariable-adjusted regression analyses were used to adjust for covariates. RESULTS: Overall, 0.9% of the study sample, representing 2.1 of 235.4 million adults, met criteria for current OUD; 1.2%, representing 2.7 million adults, met criteria for past OUD. Adults with current or past OUD had large and moderately reduced mental component (MCS) and physical health component (PCS) summary scores compared to adults who never had OUD (p < 0.001, respectively). Current OUD was associated with lower odds of being employed compared to never experiencing OUD (Adjusted odds ratio = 0.65; 95% CI: 0.48, 0.88; p = 0.005), as was past OUD. Adjustment for potentially confounding factors reduced the independent association of OUD and HRQOL by about 40-50% but did not change employment comparisons. CONCLUSION: Adults with current OUD are associated with large reductions in HRQOL and likelihood of not being employed, and adults with past OUD also have considerable residual impairment.
BACKGROUND: To examine the association of current and past Opiate Use Disorder (OUD) with measures of HRQOL and employment in a nationally representative sample of adults. METHODS: The 2012-2013 National Epidemiological Survey on Alcohol and Related Conditions III (NESARC III) surveyed a nationally representative sample of non-institutionalized civilian adults (≥18 years) in the US (n = 36,309 unweighted). Using DSM-5 criteria, adults without history of OUD were compared to those with current and past OUD. Using the SF-12 items, standard measures of the mental and physical component scores of HRQOL and of quality-adjusted life years (QALYs) were constructed. Employment in the past year (yes/no) was also assessed. Multivariable-adjusted regression analyses were used to adjust for covariates. RESULTS: Overall, 0.9% of the study sample, representing 2.1 of 235.4 million adults, met criteria for current OUD; 1.2%, representing 2.7 million adults, met criteria for past OUD. Adults with current or past OUD had large and moderately reduced mental component (MCS) and physical health component (PCS) summary scores compared to adults who never had OUD (p < 0.001, respectively). Current OUD was associated with lower odds of being employed compared to never experiencing OUD (Adjusted odds ratio = 0.65; 95% CI: 0.48, 0.88; p = 0.005), as was past OUD. Adjustment for potentially confounding factors reduced the independent association of OUD and HRQOL by about 40-50% but did not change employment comparisons. CONCLUSION: Adults with current OUD are associated with large reductions in HRQOL and likelihood of not being employed, and adults with past OUD also have considerable residual impairment.
Authors: M Chahua; A Sánchez-Niubò; M Torrens; L Sordo; M J Bravo; M T Brugal; A Domingo-Salvany Journal: Qual Life Res Date: 2015-02-15 Impact factor: 4.147
Authors: Deborah S Hasin; Eliana Greenstein; Christina Aivadyan; Malki Stohl; Efrat Aharonovich; Tulshi Saha; Rise Goldstein; Edward V Nunes; Jeesun Jung; Haitao Zhang; Bridget F Grant Journal: Drug Alcohol Depend Date: 2014-12-18 Impact factor: 4.492
Authors: Emily E Hartwell; Alison K Merikangas; Shefali S Verma; Marylyn D Ritchie; Henry R Kranzler; Rachel L Kember Journal: Addict Biol Date: 2021-10-05 Impact factor: 4.093
Authors: Ja K Gu; Penelope Allison; Alexis Grimes Trotter; Luenda E Charles; Claudia C Ma; Matthew Groenewold; Michael E Andrew; Sara E Luckhaupt Journal: J Occup Environ Med Date: 2022-01-01 Impact factor: 2.306
Authors: Melexima Simirea; Cédric Baumann; Michael Bisch; Hélène Rousseau; Paolo Di Patrizio; Sarah Viennet; Stéphanie Bourion-Bédès Journal: Health Qual Life Outcomes Date: 2022-02-16 Impact factor: 3.186