Gurbet Özge Mert1, Özcan Başaran2, Kadir Uğur Mert3, Volkan Doğan2, Bülent Özlek2, Oğuzhan Çelik2, Eda Özlek2, Cem Çil2, İbrahim Halil Özdemir4, İbrahim Rencüzoğulları5, Fatma Özpamuk Karadeniz6, Lütfü Bekar7, Müjdat Aktaş8, Mübariz Murat Resulzade9, Macit Kalçık7, Gökhan Aksan10, Göksel Çinier11, Kadriye Akay12, Nihat Pekel13, Utku Şenol14, Murat Biteker2, Meral Kayıkçıoğlu15. 1. Department of Cardiology, Eskişehir Yunus Emre State Hospital, Eskişehir, Turkey. 2. Department of Cardiology, Faculty of Medicine, Muğla Sıtkı Koçman University, Muğla, Turkey. 3. Department of Cardiology, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir, Turkey. 4. Department of Cardiology, Nizip State Hospital, Gaziantep, Turkey. 5. Department of Cardiology, Faculty of Medicine, Kafkas University, Kars, Turkey. 6. Department of Cardiology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey. 7. Department of Cardiology, Faculty of Medicine, Hitit University, Çorum, Turkey. 8. Department of Cardiology, Faculty of Medicine Regional Training and Research Hospital, Kocaeli University, Kocaeli, Turkey. 9. Department of Cardiology, Private Hospitalpark Hospital, Kocaeli, Turkey. 10. Department of Cardiology, Sıslı Hamıdıye Etfal Research and Training Hospital, İstanbul, Turkey. 11. Department of Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Center, İstanbul, Turkey. 12. Department of Cardiology, Kocaeli State Hospital, Kocaeli, Turkey. 13. Department of Cardiology, Tekden Private Hospital, Denizli, Turkey. 14. Department of Cardiology, Eskisehir Acıbadem Hospital, Eskişehir, Turkey. 15. Department of Cardiology, Ege University Faculty of Medicine, İzmir, Turkey.
Abstract
OBJECTIVE: There are lack of studies considering the suboptimal management of dyslipidemia especially in cardiology outpatient clinics. This study was conducted to assess the patient adherence to cholesterol treatment recommendations and attainment of low-density-lipoprotein cholesterol (LDL-C) goals. METHODS: EPHESUS (NCT02608645) is a national, observational and multicenter registry which has been designed as a cross-sectional study to allow inclusion of all consecutive patients with hypercholesterolemia in cardiology outpatient clinics. The present subgroup analyses of the EPHESUS trial included patients with known peripheral artery disease or atherosclerotic cerebrovascular disease, and coronary heart disease namely secondary prevention. RESULTS: The present analysis of the EPHESUS study included 1482 patients (62.79 ± 10.4 years, 38.2% female) with secondary prevention from 40 sites in Turkey. Regarding recommended lipid targets for LDL-C, only 267 patients (18%) were below the target of 70 mg/dL. Females were significantly more off-target when compared with male patients (396, 85.5% vs 67, 14.5%; P = 0.017). Moreover, the achievement of LDL-C goal was significantly decreased with illiteracy (233, 19.2% vs 35, 13.1%; P = 0.02). Patients who think that the cholesterol treatment should be terminated when the cholesterol level of a patient has normalised were higher in the off-target group (34.0% vs 24.7%, P < 0.001). Besides, physician perceptions about LDL-C goal for secondary prevention were significantly related with LDL-C target attainment. CONCLUSIONS: EPHESUS is an important study with large population in terms of representing real-life practice of the adherence to dyslipidemia guidelines in secondary prevention patients in Turkey. Perceptions, knowledge, and compliance with the guidelines for secondary prevention have increased, but it is far below from the desired levels even in cardiology outpatient clinics. There is a need for patients' and physicians' education regarding the treatment of hyperlipidemia.
OBJECTIVE: There are lack of studies considering the suboptimal management of dyslipidemia especially in cardiology outpatient clinics. This study was conducted to assess the patient adherence to cholesterol treatment recommendations and attainment of low-density-lipoprotein cholesterol (LDL-C) goals. METHODS: EPHESUS (NCT02608645) is a national, observational and multicenter registry which has been designed as a cross-sectional study to allow inclusion of all consecutive patients with hypercholesterolemia in cardiology outpatient clinics. The present subgroup analyses of the EPHESUS trial included patients with known peripheral artery disease or atherosclerotic cerebrovascular disease, and coronary heart disease namely secondary prevention. RESULTS: The present analysis of the EPHESUS study included 1482 patients (62.79 ± 10.4 years, 38.2% female) with secondary prevention from 40 sites in Turkey. Regarding recommended lipid targets for LDL-C, only 267 patients (18%) were below the target of 70 mg/dL. Females were significantly more off-target when compared with male patients (396, 85.5% vs 67, 14.5%; P = 0.017). Moreover, the achievement of LDL-C goal was significantly decreased with illiteracy (233, 19.2% vs 35, 13.1%; P = 0.02). Patients who think that the cholesterol treatment should be terminated when the cholesterol level of a patient has normalised were higher in the off-target group (34.0% vs 24.7%, P < 0.001). Besides, physician perceptions about LDL-C goal for secondary prevention were significantly related with LDL-C target attainment. CONCLUSIONS: EPHESUS is an important study with large population in terms of representing real-life practice of the adherence to dyslipidemia guidelines in secondary prevention patients in Turkey. Perceptions, knowledge, and compliance with the guidelines for secondary prevention have increased, but it is far below from the desired levels even in cardiology outpatient clinics. There is a need for patients' and physicians' education regarding the treatment of hyperlipidemia.
Authors: Jose Javier Gomez-Barrado; Paula Gomez-Turegano; Carolina Ortiz-Cortes; Jorge Vega-Fernandez; Marta Gomez-Turegano; Francisco Javier Garciperez de Vargas; Luis Enrique Lezcano Gort; Zineb Kounka; Benjamin Roque Rodriguez; David Chipayo Gonzales; Paloma Perez-Espejo; Ana Isabel Fernandez-Chamorro; Maria Beltran Moreno; Maria Jose Romero Castro; Maria Victoria Mogollon Jimenez; Gonzalo Marcos Gomez; Yolanda Porras Ramos Journal: Cardiol Res Date: 2020-08-01