Enhancing surface-assisted laser desorption ionization mass spectrometry performance by integrating plasmonic hot-electron transfer effect through surface modification.

Surface-assisted laser desorption ionization mass spectrometry (SALDI MS) performances were enhanced by modifying surfaces to include a plasmonic hot-electron transfer effect. After modification, the core material's specificity was not only maintained but also enhanced. The MS imaging of ischemic tissues with the modified material indicated some sulfatide changes, which have been barely reported.