| Literature DB >> 31037950 |
Kevin J Selva1, Jennifer A Juno1, Matthew J Worley1, Amy W Chung1, Gilda Tachedjian1,2,3, Stephen J Kent1,4,5, Matthew S Parsons1.
Abstract
Most HIV-1 transmissions occur at mucosae and involve exposure to semen. Semen contains immunomodulatory factors, which inhibit anti-HIV-1 natural killer cell and T cell responses. We demonstrate high concentrations (1:2 dilution) of seminal plasma (SP) inhibit monocyte phagocytosis and anti-HIV-1 Fc-dependent functions of both neutrophils and monocytes. In addition, slightly lower SP concentrations (1:2-1:10 dilutions) inhibit granulocyte phagocytosis and oxidative burst of both monocytes and granulocytes. These observations may have implications for HIV-1 infectivity after mucosal exposure.Entities:
Keywords: Fc receptors; HIV-1; antibodies; granulocytes; monocytes; semen
Year: 2019 PMID： 31037950 DOI： 10.1089/AID.2018.0219
Source DB: PubMed Journal: AIDS Res Hum Retroviruses ISSN： 0889-2229 Impact factor: 2.205