Literature DB >> 3103619

Inhibition of mitochondrial NADH-ubiquinone oxidoreductase activity by 1-methyl-4-phenylpyridinium ion.

Y Mizuno, T Saitoh, N Sone.   

Abstract

Effect of 1-methyl-4-phenylpyridinium ion (MPP+) on the activity of NADH-ubiquinone oxidoreductase was studied using mitochondria prepared from rat brains. At first, inhibition of oxygen consumption by MPP+ with pyruvate + malate or glutamate + malate as substrates was confirmed polarographically using a Clark-type oxygen electrode. Then, activity of NADH-ubiquinone oxidoreductase in the same samples used in polarography was assayed. Incubation of mitochondria with 0.05 mM of MPP+ together with glutamate, malate and ADP resulted in approximately 50% inhibition of NADH-ubiquinone oxidoreductase activity. Significance of the results was discussed with respect to the mechanism of neuronal degeneration by MPP+.

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Year:  1987        PMID： 3103619     DOI： 10.1016/0006-291x(87)90664-4

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  14 in total

1.  The protective role of D-glucose against 1-methyl-4-phenylpyridinium ion (MPP+): induced mitochondrial dysfunction in C6 astroglial cells.

Authors:  Ramesh B Badisa; Selina F Darling-Reed; Karam F A Soliman
Journal:  Neurochem Res       Date:  2010-05-28       Impact factor: 3.996

Review 2.  Progress in the pathogenesis and genetics of Parkinson's disease.

Authors:  Yoshikuni Mizuno; Nobutaka Hattori; Shin-Ichiro Kubo; Shigeto Sato; Kenya Nishioka; Taku Hatano; Hiroyuki Tomiyama; Manabu Funayama; Yutaka Machida; Hideki Mochizuki
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2008-06-27       Impact factor: 6.237

3.  Cerebrospinal fluid lactate and pyruvate concentrations in patients with Parkinson's disease and mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS)

Authors:  M Yamamoto; H Ujike; K Wada; T Tsuji
Journal:  J Neurol Neurosurg Psychiatry       Date:  1997-03       Impact factor: 10.154

4.  Localization of a gene for an autosomal recessive form of juvenile Parkinsonism to chromosome 6q25.2-27.

Authors:  H Matsumine; M Saito; S Shimoda-Matsubayashi; H Tanaka; A Ishikawa; Y Nakagawa-Hattori; M Yokochi; T Kobayashi; S Igarashi; H Takano; K Sanpei; R Koike; H Mori; T Kondo; Y Mizutani; A A Schäffer; Y Yamamura; S Nakamura; S Kuzuhara; S Tsuji; Y Mizuno
Journal:  Am J Hum Genet       Date:  1997-03       Impact factor: 11.025

Review 5.  The bimodal mechanism of interaction between dopamine and mitochondria as reflected in Parkinson's disease and in schizophrenia.

Authors:  Dorit Ben-Shachar
Journal:  J Neural Transm (Vienna)       Date:  2019-12-17       Impact factor: 3.575

6.  The unintended mitochondrial uncoupling effects of the FDA-approved anti-helminth drug nitazoxanide mitigates experimental parkinsonism in mice.

Authors:  Niharika Amireddy; Srinivas N Puttapaka; Ravali L Vinnakota; Halley G Ravuri; Swaroop Thonda; Shasi V Kalivendi
Journal:  J Biol Chem       Date:  2017-08-10       Impact factor: 5.157

7.  Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants.

Authors:  Jessica C Greene; Alexander J Whitworth; Isabella Kuo; Laurie A Andrews; Mel B Feany; Leo J Pallanck
Journal:  Proc Natl Acad Sci U S A       Date:  2003-03-17       Impact factor: 11.205

Review 8.  Parkinson's disease and mitochondrial complex I: a perspective on the Ndi1 therapy.

Authors:  Mathieu Marella; Byoung Boo Seo; Takao Yagi; Akemi Matsuno-Yagi
Journal:  J Bioenerg Biomembr       Date:  2009-12       Impact factor: 2.945

9.  Inhibition of mitochondrial respiration by 1,2,3,4-tetrahydroisoquinoline-like endogenous alkaloids in mouse brain.

Authors:  K Suzuki; Y Mizuno; M Yoshida
Journal:  Neurochem Res       Date:  1990-07       Impact factor: 3.996

10.  Oxidative stress in skin fibroblasts cultures from patients with Parkinson's disease.

Authors:  Pilar del Hoyo; Alberto García-Redondo; Fernando de Bustos; José Antonio Molina; Youssef Sayed; Hortensia Alonso-Navarro; Luis Caballero; Joaquín Arenas; José A G Agúndez; Félix Javier Jiménez-Jiménez
Journal:  BMC Neurol       Date:  2010-10-19       Impact factor: 2.474
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