Aleksandar Perić1, Sandra Vezmar Kovačević2, Aleksandra Barać3, Dejan Gaćeša4, Aneta V Perić5, Svjetlana Matković Jožin6. 1. a Department of Otorhinolaryngology, Faculty of Medicine, Military Medical Academy , University of Defense , Belgrade , Serbia. 2. b Department of Pharmacokinetics and Clinical Pharmacy, Faculty of Pharmacy , University in Belgrade , Belgrade , Serbia. 3. c Clinical Center of Serbia, School of Medicine , University in Belgrade , Belgrade , Serbia. 4. d ENT Hospital "Dr. Zutic" , Belgrade , Serbia. 5. e Institute for Pharmacy, Faculty of Medicine, Military Medical Academy , University of Defense , Belgrade , Serbia. 6. f ENT Department , Lovisenberg Diakonale Hospital , Oslo , Norway.
Abstract
BACKGROUND:Aspirin-induced chronic rhinosinusitis (CRS) is a severe progressive persistent disease, usually associated with nasal polyps (NPs). AIM/ OBJECTIVE: To compare effect of hypertonic (2.3% NaCl) sea water and isotonic 0.9% NaCl on symptoms and endoscopic findings in those patients in the period of 1 month after endoscopic sinus surgery (ESS). MATERIAL AND METHODS: This prospective, randomized study included 30 patients with aspirin-induced CRS undergoing ESS. Patients were divided into two groups of 15 subjects and one of the two nasal irrigation solutions was administered in each group. Intensity of 5 symptoms (nasal obstruction, nasal discharge/postnasal drip, facial pain/pressure, headache and trouble sleeping) and endoscopic findings were assessed during the 1st, 7th, 14th, 21st and 28th days after the nasal packs removal. RESULTS: We found significantly lower total symptom score (TSS) during the 7th (p = .009), 14th (p = .003), 21st (p < .001) and the 28th day (p = .001), lower total endoscopic score (TES) on the 21st (p = .002) and 28th day (p = .001), lower nasal obstruction, facial pain/pressure, headache and trouble sleeping, and lower nasal mucosal edema, nasal secretion and nasal crusting in patients treated by hypertonic sea water. CONCLUSION AND SIGNIFICANCE: Hypertonic sea water should be recommended douching solution in the early postoperative care of patients with aspirin-induced CRS.
RCT Entities:
BACKGROUND:Aspirin-induced chronic rhinosinusitis (CRS) is a severe progressive persistent disease, usually associated with nasal polyps (NPs). AIM/ OBJECTIVE: To compare effect of hypertonic (2.3% NaCl) sea water and isotonic 0.9% NaCl on symptoms and endoscopic findings in those patients in the period of 1 month after endoscopic sinus surgery (ESS). MATERIAL AND METHODS: This prospective, randomized study included 30 patients with aspirin-induced CRS undergoing ESS. Patients were divided into two groups of 15 subjects and one of the two nasal irrigation solutions was administered in each group. Intensity of 5 symptoms (nasal obstruction, nasal discharge/postnasal drip, facial pain/pressure, headache and trouble sleeping) and endoscopic findings were assessed during the 1st, 7th, 14th, 21st and 28th days after the nasal packs removal. RESULTS: We found significantly lower total symptom score (TSS) during the 7th (p = .009), 14th (p = .003), 21st (p < .001) and the 28th day (p = .001), lower total endoscopic score (TES) on the 21st (p = .002) and 28th day (p = .001), lower nasal obstruction, facial pain/pressure, headache and trouble sleeping, and lower nasal mucosal edema, nasal secretion and nasal crusting in patients treated by hypertonic sea water. CONCLUSION AND SIGNIFICANCE: Hypertonic sea water should be recommended douching solution in the early postoperative care of patients with aspirin-induced CRS.
Authors: Danijela Štanfel; Livije Kalogjera; Sergej V Ryazantsev; Kristina Hlača; Elena Y Radtsig; Rashidov Teimuraz; Pero Hrabač Journal: Mar Drugs Date: 2022-05-17 Impact factor: 6.085