Mohit Pahuja1, Oluwole Adegbala2, Tushar Mishra3, Emmanuel Akintoye4, Omar Chehab3, Shruti Mony5, Manmohan Singh1, Tomo Ando1, Hossam Abubaker3, Ahmed Yassin3, Ahmed Subahi3, Mohamed Shokr1, Sagar Ranka6, Alexandros Briasoulis4, Navin K Kapur7, Daniel Burkhoff8, Luis Afonso9. 1. Division of Cardiology, Department of Inernal Medicine, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan. 2. Department of Internal Medicine, Engelwood Hospital and Medical Center, Seton Hall University-Hackensack Meridian School of Medicine, Engelwood, New Jersey. 3. Department of Inernal Medicine, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan. 4. Division of Cardiology, Departement of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa. 5. Division of Gastroenterology, University of South Florida, Tampa, Florida. 6. Department of Internal Medicine, Cook County Hospital, Chicago, Illinios. 7. Division of Cardiology, Department of Internal Medicine, Tufts Medical Center. 8. Cardiovascular Research Foundation; Division of Cardiology, Department of Internal Medicine, Columbia University Medical Center, New York, New York. 9. Division of Cardiology, Department of Inernal Medicine, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan. Electronic address: lafonso@med.wayne.edu.
Abstract
BACKGROUND: Myocarditis may be associated with hemodynamic instability and portends a poor prognosis when associated with cardiogenic shock (CS). There are limited data available on the incidence of in-hospital mortality, CS, and utilization of mechanical circulatory support (MCS) devices in these patients. METHODS: We queried the 2005-2014 National Inpatient Sample databases to identify all patients aged >18 years with myocarditis in the United States. RESULTS: The number of reported cases of myocarditis per 1 million gradually increased from 95 in 2005 to 144 in 2014 (Pfor trend <.01). The trend and incidence of endomyocardial biopsy remained the same despite the increase in clinical diagnosis. Overall, in-hospital mortality was 4.43% of total admissions without a change in overall trend over the study period. We also observed a significant increase in the incidence of CS from 6.94% in 2005 to 11.99% in 2014 (Pfor trend <.01). There was a parallel increase in the utilization of advanced MCS devices during the same time period such as extracorporeal membrane oxygenation or percutaneous cardiopulmonary support (0.32% in 2005 to 2.1% in 2014; P< .01) and percutaneous ventricular assist devices such as Impella/tandem heart (0.176% in 2005 to 1.75% in 2014; P< .01). CONCLUSION: Although the incidence of myocarditis has increased in the last decade, the in-hospital mortality has remained the same despite increases in the incidence of CS, possibly reflecting the benefits of increased usage of advanced MCS devices. We noted that increasing age, presence of multiple comorbidities and CS were associated with an increase in in-patient mortality.
BACKGROUND:Myocarditis may be associated with hemodynamic instability and portends a poor prognosis when associated with cardiogenic shock (CS). There are limited data available on the incidence of in-hospital mortality, CS, and utilization of mechanical circulatory support (MCS) devices in these patients. METHODS: We queried the 2005-2014 National Inpatient Sample databases to identify all patients aged >18 years with myocarditis in the United States. RESULTS: The number of reported cases of myocarditis per 1 million gradually increased from 95 in 2005 to 144 in 2014 (Pfor trend <.01). The trend and incidence of endomyocardial biopsy remained the same despite the increase in clinical diagnosis. Overall, in-hospital mortality was 4.43% of total admissions without a change in overall trend over the study period. We also observed a significant increase in the incidence of CS from 6.94% in 2005 to 11.99% in 2014 (Pfor trend <.01). There was a parallel increase in the utilization of advanced MCS devices during the same time period such as extracorporeal membrane oxygenation or percutaneous cardiopulmonary support (0.32% in 2005 to 2.1% in 2014; P< .01) and percutaneous ventricular assist devices such as Impella/tandem heart (0.176% in 2005 to 1.75% in 2014; P< .01). CONCLUSION: Although the incidence of myocarditis has increased in the last decade, the in-hospital mortality has remained the same despite increases in the incidence of CS, possibly reflecting the benefits of increased usage of advanced MCS devices. We noted that increasing age, presence of multiple comorbidities and CS were associated with an increase in in-patientmortality.
Authors: Shreyas Venkataraman; Abhishek Bhardwaj; Peter Matthew Belford; Benjamin N Morris; David X Zhao; Saraschandra Vallabhajosyula Journal: Medicina (Kaunas) Date: 2022-02-01 Impact factor: 2.430
Authors: Filio Billia; Ana Carolina Alba; Julie K K Vishram-Nielsen; Farid Foroutan; Saima Rizwan; Serena S Peck; Julia Bodack; Ani Orchanian-Cheff; Finn Gustafsson; Heather J Ross; Eddy Fan; Vivek Rao Journal: Heart Fail Rev Date: 2022-10-07 Impact factor: 4.654
Authors: Enrico Ammirati; Maria Frigerio; Leslie T Cooper; Paolo G Camici; Eric D Adler; Cristina Basso; David H Birnie; Michela Brambatti; Matthias G Friedrich; Karin Klingel; Jukka Lehtonen; Javid J Moslehi; Patrizia Pedrotti; Ornella E Rimoldi; Heinz-Peter Schultheiss; Carsten Tschöpe Journal: Circ Heart Fail Date: 2020-11-12 Impact factor: 8.790