| Literature DB >> 31034962 |
A Francesca Setiadi1, Alexander R Abbas1, Surinder Jeet1, Kit Wong1, Antje Bischof2, Ivan Peng1, James Lee1, Meire Bremer1, Erica L Eggers3, Jason DeVoss1, Tracy Staton1, Ann Herman1, H-Christian von Büdingen3, Michael J Townsend4.
Abstract
IL-17 has been implicated in the pathogenesis of multiple sclerosis (MS). Here, we show that blockade of IL-17A, but not IL-17F, attenuated experimental autoimmune encephalomyelitis (EAE). We further show that IL-17A levels were elevated in the CSF of relapsing-remitting MS (RRMS) patients and that they correlated with the CSF/serum albumin quotient (Qalb), a measure of blood-brain barrier (BBB) dysfunction. We then demonstrated that the combination of IL-17A and IL-6 reduced the expression of tight junction (TJ)-associated genes and disrupted monolayer integrity in the BBB cell line hCMEC/D3. However, unlike IL-17A, IL-6 in the CSF from RRMS patients did not correlate with Qalb. These data highlight the potential importance of targeting IL-17A in preserving BBB integrity in RRMS.Entities:
Year: 2019 PMID： 31034962 DOI： 10.1016/j.jneuroim.2019.04.011
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478