Esther J M de Brouwer1, Remko Kockelkoren2, Jill B De Vis2, Jan Willem Dankbaar2, Birgitta K Velthuis2, Richard Ap Takx2, Annemarieke De Jonghe3, Marielle H Emmelot-Vonk4, Huiberdina L Koek4, Pim A de Jong2. 1. Department of Geriatrics, University Medical Center Utrecht, Room B05.2.25, PO Box 85500, 3508 GA Utrecht, The Netherlands. Electronic address: E.J.M.deBrouwer-8@umcutrecht.nl. 2. Department of Radiology, University Medical Center Utrecht, Room F01.503, PO Box 85500, 3508 GA, Utrecht, The Netherlands. 3. Department of Geriatrics, Tergooi hospital, PO box 10016, 1201 DA, Hilversum, The Netherlands. 4. Department of Geriatrics, University Medical Center Utrecht, Room B05.2.25, PO Box 85500, 3508 GA Utrecht, The Netherlands.
Abstract
BACKGROUND AND PURPOSE: Risk factors for and meaning of basal ganglia calcifications outside Fahr syndrome are poorly understood. We aimed to assess the prevalence of basal ganglia calcifications and the association with vascular risk factors. MATERIALS AND METHODS: 1133 patients suspected of acute ischemic stroke from the Dutch acute stroke (DUST) study who underwent thin-slice unenhanced brain CT were analyzed. Basal ganglia calcifications were scored bilaterally as absent, mild (dot), moderate (multiple dots or single artery) and severe (confluent). Uni- and multivariable logistic regression analysis was used to determine possible risk factors (age, gender, history of stroke, smoking, hypertension, diabetes mellitus, hyperlipidemia, body mass index (BMI), renal function and family history of cardiovascular disease under 60 years) for presence of basal ganglia calcifications and ordinal regression analysis for severity of basal ganglia calcifications. RESULTS: Mean age was 67.4 years (SD: 13.8), 56.8% were male. 337 (29.7%) patients had basal ganglia calcifications, of which 196 (58%) were mild, 103 (31%) moderate, 38 (11%) severe. In multivariable logistic regression analysis, age (OR: 1.02, 95% CI 1.01-1.03, P < 0.01) and BMI (OR: 0.95, 95% CI 0.91-0.98, p 0.01) were significantly associated with the presence of basal ganglia calcifications. Ordinal regression analysis gave comparable results. Age (OR: 1.02, 95% CI 1.01-1.03, P < 0.01) and BMI (OR: 0.95, 95% CI 0.92-0.99, P 0.01) were significantly associated with severity of basal ganglia calcifications. CONCLUSIONS: In this study with patients suspected of acute ischemic stroke, basal ganglia calcifications were common and significantly associated with older age and lower BMI.
BACKGROUND AND PURPOSE: Risk factors for and meaning of basal ganglia calcifications outside Fahr syndrome are poorly understood. We aimed to assess the prevalence of basal ganglia calcifications and the association with vascular risk factors. MATERIALS AND METHODS: 1133 patients suspected of acute ischemic stroke from the Dutch acute stroke (DUST) study who underwent thin-slice unenhanced brain CT were analyzed. Basal ganglia calcifications were scored bilaterally as absent, mild (dot), moderate (multiple dots or single artery) and severe (confluent). Uni- and multivariable logistic regression analysis was used to determine possible risk factors (age, gender, history of stroke, smoking, hypertension, diabetes mellitus, hyperlipidemia, body mass index (BMI), renal function and family history of cardiovascular disease under 60 years) for presence of basal ganglia calcifications and ordinal regression analysis for severity of basal ganglia calcifications. RESULTS: Mean age was 67.4 years (SD: 13.8), 56.8% were male. 337 (29.7%) patients had basal ganglia calcifications, of which 196 (58%) were mild, 103 (31%) moderate, 38 (11%) severe. In multivariable logistic regression analysis, age (OR: 1.02, 95% CI 1.01-1.03, P < 0.01) and BMI (OR: 0.95, 95% CI 0.91-0.98, p 0.01) were significantly associated with the presence of basal ganglia calcifications. Ordinal regression analysis gave comparable results. Age (OR: 1.02, 95% CI 1.01-1.03, P < 0.01) and BMI (OR: 0.95, 95% CI 0.92-0.99, P 0.01) were significantly associated with severity of basal ganglia calcifications. CONCLUSIONS: In this study with patients suspected of acute ischemic stroke, basal ganglia calcifications were common and significantly associated with older age and lower BMI.
Authors: Margaret Gatz; Wendy J Mack; Helena C Chui; E Meng Law; Giuseppe Barisano; M Linda Sutherland; James D Sutherland; Daniel Eid Rodriguez; Raul Quispe Gutierrez; Juan Copajira Adrian; Jesus Bani Cuata; Amy R Borenstein; Ellen E Walters; Andrei Irimia; Christopher J Rowan; L Samuel Wann; Adel H Allam; Randall C Thompson; Michael I Miyamoto; David E Michalik; Daniel K Cummings; Edmond Seabright; Angela R Garcia; Paul L Hooper; Thomas S Kraft; Caleb E Finch; Gregory S Thomas; Jonathan Stieglitz; Benjamin C Trumble; Michael D Gurven; Hillard Kaplan Journal: Alzheimers Dement Date: 2022-03-09 Impact factor: 16.655
Authors: Esther J M de Brouwer; Pim A de Jong; Annemarieke De Jonghe; Marielle H Emmelot-Vonk; Huiberdina L Koek; Jan-Willem Dankbaar; Firdaus A A Mohamed Hoesein; Wim Van Hecke Journal: Neuroradiology Date: 2021-03-20 Impact factor: 2.804