| Literature DB >> 3103482 |
T H Park, K H Tachiki, W K Summers, D Kling, J Fitten, K Perryman, K Spidell, A S Kling.
Abstract
Tacrine (THA; 1,2,3,4-tetrahydro-9-aminoacridine) is an anticholinesterase agent which has been used clinically, most recently in the treatment of Alzheimer-type dementias. This paper describes the methodology for the isolation and quantitation of THA at therapeutic levels in serum from human subjects. Using C18 Bond Elut columns and an HPLC/fluorometry system, this assay exhibits a considerable improvement in sensitivity over previous uv methods, and allows routine testing of THA levels in serum samples of reasonable volume from human subjects.Entities:
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Year: 1986 PMID： 3103482 DOI： 10.1016/0003-2697(86)90353-2
Source DB: PubMed Journal: Anal Biochem ISSN： 0003-2697 Impact factor: 3.365