Literature DB >> 31033913

Increasing Diagnostic Uncertainties in Children With In Utero HIV Infection.

Jane R Millar1,2, Zodumo Mvo1, Nomonde Bengu1, Rowena Fillis1, Ken Sprenger1, Philippa C Matthews2, Moherndran Archary3, Thumbi Ndung'u4,5,6, Emily Adland2, Maria C Puertas7, Javier Martinez-Picado7,8,9, Philip Goulder2.   

Abstract

We present a case of an in utero HIV-infected child, who on day 1 of life had a positive whole blood total nucleic acid test but viral load <20 RNA copies/mL. Dried blood spot total nucleic acid testing was negative on day 1, 10 and at 3 months, while on ART prophylaxis then positive at 5 months after prophylaxis ended. Retrospective peripheral blood mononuclear cells HIV DNA testing from day 1 of life was positive, confirming in utero infection.

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Year:  2019        PMID： 31033913      PMCID： PMC7612888          DOI： 10.1097/INF.0000000000002315

Source DB:  PubMed          Journal:  Pediatr Infect Dis J        ISSN： 0891-3668            Impact factor:   3.806


  9 in total

1.  Nevirapine plus zidovudine to prevent mother-to-child transmission of HIV.

Authors:  Philip J R Goulder; Natasha Blanckenberg; Krista Dong
Journal:  N Engl J Med       Date:  2004-11-04       Impact factor: 91.245

2.  Absence of detectable HIV-1 viremia after treatment cessation in an infant.

Authors:  Deborah Persaud; Hannah Gay; Carrie Ziemniak; Ya Hui Chen; Michael Piatak; Tae-Wook Chun; Matthew Strain; Douglas Richman; Katherine Luzuriaga
Journal:  N Engl J Med       Date:  2013-10-23       Impact factor: 91.245

3.  Virologic testing in infants with perinatal exposure to HIV receiving multidrug prophylaxis.

Authors:  Maureen D Connolly; Richard M Rutstein; Elizabeth D Lowenthal
Journal:  Pediatr Infect Dis J       Date:  2013-02       Impact factor: 2.129

4.  Rapid decline of HIV-1 DNA and RNA in infants starting very early antiretroviral therapy may pose a diagnostic challenge.

Authors:  Kirsten A Veldsman; Jean Maritz; Shahieda Isaacs; Mary G Katusiime; Anita Janse van Rensburg; Barbara Laughton; John W Mellors; Mark F Cotton; Gert U van Zyl
Journal:  AIDS       Date:  2018-03-13       Impact factor: 4.177

5.  Lymphocyte subsets in healthy children from birth through 18 years of age: the Pediatric AIDS Clinical Trials Group P1009 study.

Authors:  William T Shearer; Howard M Rosenblatt; Rebecca S Gelman; Rebecca Oyomopito; Susan Plaeger; E Richard Stiehm; Diane W Wara; Steven D Douglas; Katherine Luzuriaga; Elizabeth J McFarland; Ram Yogev; Mobeen H Rathore; Wende Levy; Bobbie L Graham; Stephen A Spector
Journal:  J Allergy Clin Immunol       Date:  2003-11       Impact factor: 10.793

6.  Discordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV Infection.

Authors:  Emily Adland; Paolo Paioni; Christina Thobakgale; Leana Laker; Luisa Mori; Maximilian Muenchhoff; Anna Csala; Margaret Clapson; Jacquie Flynn; Vas Novelli; Jacob Hurst; Vanessa Naidoo; Roger Shapiro; Kuan-Hsiang Gary Huang; John Frater; Andrew Prendergast; Julia G Prado; Thumbi Ndung'u; Bruce D Walker; Mary Carrington; Pieter Jooste; Philip J R Goulder
Journal:  PLoS Pathog       Date:  2015-06-15       Impact factor: 6.823

7.  The value of confirmatory testing in early infant HIV diagnosis programmes in South Africa: A cost-effectiveness analysis.

Authors:  Lorna Dunning; Jordan A Francke; Divya Mallampati; Rachel L MacLean; Martina Penazzato; Taige Hou; Landon Myer; Elaine J Abrams; Rochelle P Walensky; Valériane Leroy; Kenneth A Freedberg; Andrea Ciaranello
Journal:  PLoS Med       Date:  2017-11-21       Impact factor: 11.069

8.  Prevalence and outcomes of HIV-1 diagnostic challenges during universal birth testing - an urban South African observational cohort.

Authors:  Karl-Günter Technau; Ahmad Haeri Mazanderani; Louise Kuhn; Lucia Hans; Renate Strehlau; Elaine J Abrams; Martie Conradie; Ashraf Coovadia; Ndileka Mbete; Pamela M Murnane; Faeezah Patel; Stephanie Shiau; Caroline T Tiemessen; Gayle G Sherman
Journal:  J Int AIDS Soc       Date:  2017-08-29       Impact factor: 5.396

9.  High frequency of rapid immunological progression in African infants infected in the era of perinatal HIV prophylaxis.

Authors:  Wendy Mphatswe; Natasha Blanckenberg; Gareth Tudor-Williams; Andrew Prendergast; Christina Thobakgale; Nompumelelo Mkhwanazi; Noel McCarthy; Bruce D Walker; Photini Kiepiela; Philip Goulder
Journal:  AIDS       Date:  2007-06-19       Impact factor: 4.177
  9 in total
  1 in total

1.  Next-generation point-of-care testing in pediatric human immunodeficiency virus infection facilitates diagnosis and monitoring of treatment.

Authors:  Nomonde Bengu; Noxolo Mchunu; Sijabulile Mokhethi; Rowena Fillis; Gabriela Cromhout; Jeroen van Lobenstein; Yeney Graza; Constant Kapongo; Kogielambal Chinniah; Roopesh Bhoola; Emily Adland; Mari C Puertas; Thumbi Ndung'u; Javier Martinez-Picado; Moherndran Archary; Philip J R Goulder
Journal:  Medicine (Baltimore)       Date:  2022-07-08       Impact factor: 1.817
  1 in total

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