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Literature DB >> 31031441

Changes in Gene Expression in Human Epithelial and Mast Cells in Response to Vesicles from Klebsiella pneumonia ATCC 13883.

Hee Sang You^1,2, Yeon Jeong Ok¹, Song Hee Lee¹, Sang Sun Kang³, Sung Hee Hyun^1,2.

Abstract

We investigated alterations in the expression of immune-related genes in epithelial cells and mast cells treated with outer membrane vesicles (OMVs) derived from Klebsiella pneumoniae (KpOMVs). Previous studies have shown that OMVs contain substances that enable their delivery to host cells and induce an immune response. Our results indicate an increase in expression of genes such as IL-8, IL-1b, MIP-1α, HMOX1, HSPA1A, and IL-24 in epithelial cells and mast cells treated with KpOMVs. The pathogenicity of KpOMVs was confirmed by measuring the changes in the expression of these immune-related genes.

Entities: Species

Keywords: Immune related genes; Klebsiella pneumoniae; Outer membrane vesicles; Pathogen; Toxin

Year: 2018 PMID： 31031441 PMCID： PMC6458193 DOI： 10.1007/s12088-018-0774-5

Source DB: PubMed Journal: Indian J Microbiol ISSN： 0046-8991 Impact factor: 2.461

21 in total

1. Vesicle-mediated export and assembly of pore-forming oligomers of the enterobacterial ClyA cytotoxin.

Authors: Sun Nyunt Wai; Barbro Lindmark; Tomas Söderblom; Akemi Takade; Marie Westermark; Jan Oscarsson; Jana Jass; Agneta Richter-Dahlfors; Yoshimitsu Mizunoe; Bernt Eric Uhlin
Journal: Cell Date: 2003-10-03 Impact factor: 41.582

Review 2. Bacterial outer membrane vesicles and the host-pathogen interaction.

Authors: Meta J Kuehn; Nicole C Kesty
Journal: Genes Dev Date: 2005-11-15 Impact factor: 11.361

3. Interleukin-24 and its receptors.

Authors: Mai Wang; Peng Liang
Journal: Immunology Date: 2005-02 Impact factor: 7.397

4. Bactericidal effect of gentamicin-induced membrane vesicles derived from Pseudomonas aeruginosa PAO1 on gram-positive bacteria.

Authors: Kelly L MacDonald; Terry J Beveridge
Journal: Can J Microbiol Date: 2002-09 Impact factor: 2.419

5. Molecular analysis of the contribution of the capsular polysaccharide and the lipopolysaccharide O side chain to the virulence of Klebsiella pneumoniae in a murine model of pneumonia.

Authors: Guadalupe Cortés; Nuria Borrell; Beatriz de Astorza; Cristina Gómez; Jaume Sauleda; Sebastián Albertí
Journal: Infect Immun Date: 2002-05 Impact factor: 3.441

Review 1. The Contribution of Membrane Vesicles to Bacterial Pathogenicity in Cystic Fibrosis Infections and Healthcare Associated Pneumonia.

Authors: Jolien Vitse; Bart Devreese
Journal: Front Microbiol Date: 2020-04-09 Impact factor: 5.640

1 in total

Changes in Gene Expression in Human Epithelial and Mast Cells in Response to Vesicles from Klebsiella pneumonia ATCC 13883.

1. Vesicle-mediated export and assembly of pore-forming oligomers of the enterobacterial ClyA cytotoxin.

Review 2. Bacterial outer membrane vesicles and the host-pathogen interaction.

3. Interleukin-24 and its receptors.

4. Bactericidal effect of gentamicin-induced membrane vesicles derived from Pseudomonas aeruginosa PAO1 on gram-positive bacteria.

5. Molecular analysis of the contribution of the capsular polysaccharide and the lipopolysaccharide O side chain to the virulence of Klebsiella pneumoniae in a murine model of pneumonia.

6. Identification of Klebsiella pneumoniae virulence determinants using an intranasal infection model.

7. DNA-containing membrane vesicles of Pseudomonas aeruginosa PAO1 and their genetic transformation potential.

Review 8. Klebsiella and enterobacter: antibiotic resistance and treatment implications.

9. Improved methods for producing outer membrane vesicles in Gram-negative bacteria.

10. The Klebsiella pneumoniae O antigen contributes to bacteremia and lethality during murine pneumonia.

Review 1. The Contribution of Membrane Vesicles to Bacterial Pathogenicity in Cystic Fibrosis Infections and Healthcare Associated Pneumonia.