Literature DB >> 310311

E-rosette-forming cells at 29 degrees C: an assay for the evaluation of the immune status of cancer patients.

P C Quan, P Burtin.   

Abstract

High-affinity rosette-forming T-cell assays were performed by incubation of peripheral-blood mononuclear cells with sheep erythrocytes (E) at 29 degrees C. As compared with normal controls, the levels of high-affinity rosette-forming cells (RFC) were much more frequently depressed in cancer patients than were the total E-RFC incubated at 4 degrees C. Only 2/83 normal controls had less than 38% 29 degrees C E-RFC (mean 48 +/- 5), whilst 78/89 cancer patients were below this level. The few postoperative patients tested exhibited a normal range of 29 degrees C E-RFC. The 29 degrees C E-rosette assay gives reproducible counts of a T-cell subset, and is a sensitive assay for evaluating the immune status of cancer patients.

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Mesh：

Year:  1978        PMID： 310311      PMCID： PMC2009783          DOI： 10.1038/bjc.1978.256

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  19 in total

1.  Human T lymphocyte subpopulations: correlation between E-rosette-forming affinity and expression of the Fc receptor.

Authors:  W H West; S M Payne; J L Weese; R B Herberman
Journal:  J Immunol       Date:  1977-08       Impact factor: 5.422

2.  Relationship between T lymphocyte levels and lymphoproliferative responses to mitogens and alloantigens in lung and breast cancer patients.

Authors:  T R Jerrells; J H Dean; R B Herberman
Journal:  Int J Cancer       Date:  1978-03-15       Impact factor: 7.396

3.  Cell-mediated immune status of breast cancer patients: evaluation by skin tests, lymphocyte stimulation, and counts of rosette-forming cells.

Authors:  T Nemoto; T Han; J Minowada; V Angkur; A Chamberlain; L Dao
Journal:  J Natl Cancer Inst       Date:  1974-09       Impact factor: 13.506

4.  New formulation of digoxin.

Authors: 
Journal:  Lancet       Date:  1972-10-28       Impact factor: 79.321

5.  Crohn's disease and carcinoma of colon.

Authors:  A D Perrett; S C Truelove; G R Massarella
Journal:  Br Med J       Date:  1968-05-25

6.  Low affinity E-rosette formation by the human K cell.

Authors:  W H West; R B Boozer; R B Herberman
Journal:  J Immunol       Date:  1978-01       Impact factor: 5.422

7.  Depressed in vitro peripheral blood lymphocyte response to mitogens in cancer patients: the role of suppressor cells.

Authors:  M Zembala; B Mytar; T Popiela; G L Asherson
Journal:  Int J Cancer       Date:  1977-05-15       Impact factor: 7.396

8.  T and B lymphocytes in breast cancer stage relationship and abrogation of T-lymphocyte depression by enzyme treatment in vitro.

Authors:  R H Whitehead; J Thatcher; C Teasdale; G P Roberts; L E Hughes
Journal:  Lancet       Date:  1976-02-14       Impact factor: 79.321

9.  Demonstration of nonspecific suppressor cells in the peripheral lymphocytes of cancer patients.

Authors:  P C Quan; P Burtin
Journal:  Cancer Res       Date:  1978-02       Impact factor: 12.701

10.  Importance of methodology in demonstrating depression of T-lymphocyte levels.

Authors:  R H Whitehead; G P Roberts; L E Hughes; J Thatcher
Journal:  Br J Cancer       Date:  1978-01       Impact factor: 7.640
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  1 in total

1.  Lymphoid cells in lymph nodes and peripheral blood of patients with squamous cell carcinoma of the head and neck.

Authors:  R Roubin; F Bekkoucha; M C Fondaneche; P C Quan; C Micheau; Y Cachin; P Burtin
Journal:  J Cancer Res Clin Oncol       Date:  1982       Impact factor: 4.553
  1 in total

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