[Tumor metastasis in patients with non-small cell lung cancer is inversely correlated with the number of tumor-infiltrating CD8+ T cells].

Objective To analyze the relationship between the number of invasive T cells in in situ tumors and the clinical metastasis and prognosis in patients with non-small cell lung cancer (NSCLC). Methods A total of 140 lung cancer patients (including 43 cases with metastasis) were selected to observe the infiltration state of CD4+ T cells and CD8+ T cells in tumor tissues by immunohistochemical staining. The infiltration of CD4+ T cells and CD8+ T cells were compared between non-metastatic and metastatic patients. The effects of different infiltration levels of CD4+ T cells and CD8+ T cells on clinical prognosis were analyzed. Results The proportion of CD4+ T cells in the tumor tissues of the two groups was not significantly different. The number of CD8+ T cells in the metastatic group was significantly lower than that in the metastatic group, and the ratio of CD8/CD4 in the non-metastasis group was remarkably higher than that in the metastatic group. Patients with high CD8+ T cell infiltration level or high ratio of CD8/CD4 have a significantly better overall survival rate than the patients with low CD8+ T cell infiltration level or low ratio of CD8/CD4. Conclusion The number of CD8+ T cell infiltration and CD8/CD4 ratio in the tumor tissues of patients with metastatic NSCLC are significantly reduced, which is closely related to the poor prognosis of patients with NSCLC metastasis.