Justin J Alexander1, Simon N Bell2, Jennifer Coghlan3, Reto Lerf4, Frank Dallmann5. 1. Melbourne Shoulder and Elbow Centre, Brighton, VIC, Australia. 2. Melbourne Shoulder and Elbow Centre, Brighton, VIC, Australia; Department of Surgery, School of Clinical Sciences Monash Health, Monash University, Clayton, VIC, Australia. Electronic address: snbell@bigpond.net.au. 3. Department of Surgery, School of Clinical Sciences Monash Health, Monash University, Clayton, VIC, Australia. 4. Department of Research and Development, Mathys Ltd Bettlach, Bettlach, Switzerland. 5. Department of Research and Development, Mathys Orthopädie GmbH, Mörsdorf, Germany.
Abstract
BACKGROUND: Wear of the polyethylene glenoid component and subsequent particle-induced osteolysis remains one of the most important modes of failure of total shoulder arthroplasty. Vitamin E is added to polyethylene to act as an antioxidant to stabilize free radicals that exist as a byproduct of irradiation used to induce cross-linking. This study was performed to assess the in vitro performance of vitamin E-enhanced polyethylene compared with conventional polyethylene in a shoulder simulator model. METHODS: Vitamin E-enhanced, highly cross-linked glenoid components were compared with conventional ultrahigh-molecular-weight polyethylene glenoids, both articulating with a ceramic humeral head component using a shoulder joint simulator over 500,000 cycles. Unaged and artificially aged comparisons were performed. Volumetric wear was assessed by gravimetric measurement, and wear particle analysis was also subsequently performed. RESULTS: Vitamin E-enhanced polyethylene glenoid components were found to have significantly reduced wear rates compared with conventional polyethylene in both unaged (36% reduction) and artificially aged (49% reduction) comparisons. There were no differences detected in wear particle analysis between the 2 groups. CONCLUSION: Vitamin E-enhanced polyethylene demonstrates improved wear compared with conventional polyethylene in both unaged and artificially aged comparisons and may have clinically relevant benefits.
BACKGROUND: Wear of the polyethylene glenoid component and subsequent particle-induced osteolysis remains one of the most important modes of failure of total shoulder arthroplasty. Vitamin E is added to polyethylene to act as an antioxidant to stabilize free radicals that exist as a byproduct of irradiation used to induce cross-linking. This study was performed to assess the in vitro performance of vitamin E-enhanced polyethylene compared with conventional polyethylene in a shoulder simulator model. METHODS:Vitamin E-enhanced, highly cross-linked glenoid components were compared with conventional ultrahigh-molecular-weight polyethylene glenoids, both articulating with a ceramic humeral head component using a shoulder joint simulator over 500,000 cycles. Unaged and artificially aged comparisons were performed. Volumetric wear was assessed by gravimetric measurement, and wear particle analysis was also subsequently performed. RESULTS:Vitamin E-enhanced polyethylene glenoid components were found to have significantly reduced wear rates compared with conventional polyethylene in both unaged (36% reduction) and artificially aged (49% reduction) comparisons. There were no differences detected in wear particle analysis between the 2 groups. CONCLUSION:Vitamin E-enhanced polyethylene demonstrates improved wear compared with conventional polyethylene in both unaged and artificially aged comparisons and may have clinically relevant benefits.
Authors: Richard S Page; Angela C Alder-Price; Sophia Rainbird; Stephen E Graves; Richard N de Steiger; Yi Peng; Carl Holder; Michelle F Lorimer; Stephen D Gill Journal: Clin Orthop Relat Res Date: 2022-06-28 Impact factor: 4.755
Authors: Maciej J K Simon; Jennifer A Coghlan; Jeff Hughes; Warwick Wright; Richard J Dallalana; Simon N Bell Journal: BMC Musculoskelet Disord Date: 2022-01-15 Impact factor: 2.362