Hatem Hosny1, Yasser Sedky2, Soha Romeih3, Walid Simry1, Ahmed Afifi1, Amr Elsawy4, Mohamed Abdul Khalek4, Ramy Doss5, Ahmed Elguindy6, Heba Aguib7, Magdi Yacoub8. 1. Department of Cardiac Surgery, Aswan Heart Centre, Aswan, Egypt. 2. Department of Pediatrics, Cairo University, Cairo, Egypt; Department of Pediatric Cardiology, Aswan Heart Centre, Aswan, Egypt. 3. Department of Pediatric Cardiology, Aswan Heart Centre, Aswan, Egypt; Department of Radiology, Aswan Heart Centre, Aswan, Egypt. 4. Biomedical Engineering and Innovation Laboratory, Aswan Heart Centre, Aswan, Egypt. 5. Department of Cardiology, Aswan Heart Centre, Aswan, Egypt. 6. Department of Cardiology, Aswan Heart Centre, Aswan, Egypt; National Heart and Lung Institute, Imperial College London, London, United Kingdom. 7. Biomedical Engineering and Innovation Laboratory, Aswan Heart Centre, Aswan, Egypt; National Heart and Lung Institute, Imperial College London, London, United Kingdom. 8. Department of Cardiac Surgery, Aswan Heart Centre, Aswan, Egypt; National Heart and Lung Institute, Imperial College London, London, United Kingdom. Electronic address: m.yacoub@imperial.ac.uk.
Abstract
OBJECTIVE: The neonatal arterial switch operation is currently the procedure of choice for patients with transposition of the great arteries. However, a large number of patients present too late for the arterial switch operation and are best managed with the atrial switch operation. METHODS: We have used the Mustard operation in its original form or following a new modification designed to enhance the atrial functions and filling of the left ventricle in an attempt to improve long-term results. RESULTS: Between July 2013 and November 2018, a total of 101 patients underwent the Mustard operation, 86 with the new modification. The median age at operation was 16 months (6 months to 27 years). A total of 75 patients (74.3%) were male. Median preoperative oxygen saturation was 71%. There were no early deaths and there were 3 late deaths during a median follow-up period of 24.2 months (all in patients with large ventricular septal defect and established pulmonary vascular disease). At the latest follow-up, all patients were in stable sinus rhythm. There were no baffle leaks. Seven patients had asymptomatic narrowing of the superior baffle, and 1 patient required balloon dilatation. Follow-up is 100% complete and includes computed tomography and magnetic resonance imaging at regular intervals (75 patients to date). Computerized analysis of representative subsets showed enhanced rate and pattern of filling of the left ventricle in the modified operation compared with the classic operation. CONCLUSIONS: The use of the Mustard operation, particularly the modified technique should play an important role in treating late-presenting patients with transposition of the great arteries. Improving the pattern of filling of the left ventricle could enhance the long-term results of the Mustard operation.
OBJECTIVE: The neonatal arterial switch operation is currently the procedure of choice for patients with transposition of the great arteries. However, a large number of patients present too late for the arterial switch operation and are best managed with the atrial switch operation. METHODS: We have used the Mustard operation in its original form or following a new modification designed to enhance the atrial functions and filling of the left ventricle in an attempt to improve long-term results. RESULTS: Between July 2013 and November 2018, a total of 101 patients underwent the Mustard operation, 86 with the new modification. The median age at operation was 16 months (6 months to 27 years). A total of 75 patients (74.3%) were male. Median preoperative oxygen saturation was 71%. There were no early deaths and there were 3 late deaths during a median follow-up period of 24.2 months (all in patients with large ventricular septal defect and established pulmonary vascular disease). At the latest follow-up, all patients were in stable sinus rhythm. There were no baffle leaks. Seven patients had asymptomatic narrowing of the superior baffle, and 1 patient required balloon dilatation. Follow-up is 100% complete and includes computed tomography and magnetic resonance imaging at regular intervals (75 patients to date). Computerized analysis of representative subsets showed enhanced rate and pattern of filling of the left ventricle in the modified operation compared with the classic operation. CONCLUSIONS: The use of the Mustard operation, particularly the modified technique should play an important role in treating late-presenting patients with transposition of the great arteries. Improving the pattern of filling of the left ventricle could enhance the long-term results of the Mustard operation.