Literature DB >> 31028889

Ferritin-based anticancer metallodrug delivery: Crystallographic, analytical and cytotoxicity studies.

Dara Maria Monti1, Giarita Ferraro1, Antonello Merlino2.   

Abstract

The encapsulation of anticancer metal-based drugs within a protein nanocage represents a valuable strategy to improve the efficacy and selectivity of these compounds towards cancer cells. The preparation, characterization of the in vitro cytotoxicity and X-ray structures of several ferritin-metallodrug nanocomposites (mainly containing platinum-, ruthenium- and gold-based anticancer agents) are here reviewed. The molecular mechanisms of action of these Ft-metallodrug adducts are discussed and future directions in the field are outlined.
Copyright © 2019 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Drug carrier; Drug delivery; Ferritin nanoparticles; Metal-based drugs; Protein nanocages

Mesh：

Substances：

Year:  2019        PMID： 31028889     DOI： 10.1016/j.nano.2019.04.001

Source DB:  PubMed          Journal:  Nanomedicine        ISSN： 1549-9634            Impact factor:   5.307


  7 in total

1.  Ferritin Nanocage Conjugated Hybrid Hydrogel for Tissue Engineering and Drug Delivery Applications.

Authors:  Roya Samanipour; Ting Wang; Moritz Werb; Hamed Hassannezhad; Juan Manuel Ledesma Rangel; Mina Hoorfar; Anwarul Hasan; Chang Kee Lee; Su Ryon Shin
Journal:  ACS Biomater Sci Eng       Date:  2019-11-05

Review 2.  In search of effective therapies to overcome resistance to Temozolomide in brain tumours.

Authors:  Kaouthar Bouzinab; Helen Summers; Jihong Zhang; Malcolm F G Stevens; Christopher J Moody; Lyudmila Turyanska; Neil R Thomas; Pavel Gershkovich; Marianne B Ashford; Emily Vitterso; Lisa C D Storer; Richard Grundy; Tracey D Bradshaw
Journal:  Cancer Drug Resist       Date:  2019-12-19

3.  A photosynthesis-inspired supramolecular system: caging photosensitizer and photocatalyst in apoferritin.

Authors:  Weijian Chen; Xuetong Cai; Luyang Ji; Xiao Li; Xuewei Wang; Xiaoran Zhang; Yajing Gao; Fude Feng
Journal:  Photosynth Res       Date:  2019-09-14       Impact factor: 3.573

4.  Arsenoplatin-Ferritin Nanocage: Structure and Cytotoxicity.

Authors:  Giarita Ferraro; Alessandro Pratesi; Damiano Cirri; Paola Imbimbo; Daria Maria Monti; Luigi Messori; Antonello Merlino
Journal:  Int J Mol Sci       Date:  2021-02-13       Impact factor: 5.923

5.  Metallodrugs: Mechanisms of Action, Molecular Targets and Biological Activity.

Authors:  Giarita Ferraro; Antonello Merlino
Journal:  Int J Mol Sci       Date:  2022-03-23       Impact factor: 5.923

6.  Protein encapsulation within the internal cavity of a bacterioferritin.

Authors:  Justin M Bradley; Elizabeth Gray; Jake Richardson; Geoffrey R Moore; Nick E Le Brun
Journal:  Nanoscale       Date:  2022-09-02       Impact factor: 8.307

Review 7.  Application Perspectives of Nanomedicine in Cancer Treatment.

Authors:  Shanshan Hou; Muhammad Hasnat; Ziwei Chen; Yinong Liu; Mirza Muhammad Faran Ashraf Baig; Fuhe Liu; Zelong Chen
Journal:  Front Pharmacol       Date:  2022-07-01       Impact factor: 5.988
  7 in total

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