Rufus Akinyemi1,2, Akin Ojagbemi3, Joshua Akinyemi4, Ayodeji Salami5, Funmi Olopade6, Temitope Farombi7, Michael Nweke5, Ezinne Uvere8, Mayowa Aridegbe9, James Balogun10, Godwin Ogbole11, Ayodele Jegede12, Rajesh Kalaria13, Adesola Ogunniyi8, Mayowa Owolabi8, Oyedunni Arulogun14. 1. Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria. rufusakinyemi@yahoo.com. 2. Neuroscience and Ageing Research Unit, College of Medicine, University of Ibadan, Ibadan, Nigeria. rufusakinyemi@yahoo.com. 3. Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria. 4. Department of Epidemiology and Medical Statistics, College of Medicine, University of Ibadan, Ibadan, Nigeria. 5. Department of Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria. 6. Department of Anatomy, College of Medicine, University of Ibadan, Ibadan, Nigeria. 7. Chief Tony Anenih Geriatric Centre, University College Hospital, Ibadan, Nigeria. 8. Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria. 9. Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria. 10. Department of Surgery, College of Medicine, University of Ibadan, Ibadan, Nigeria. 11. Department of Radiology, College of Medicine, University of Ibadan, Ibadan, Nigeria. 12. Department of Sociology, Faculty of the Social Sciences, University of Ibadan, Ibadan, Nigeria. 13. Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK. 14. Department of Health Promotion and Education, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Abstract
BACKGROUND: Laboratory-based studies of neurological disease patterns and mechanisms are sparse in sub-Saharan Africa. However, availability of human brain tissue resource depends on willingness towards brain donation. This study evaluated the level of willingness among outpatient clinic attendees in a Nigerian teaching hospital. METHODS: Under the auspices of the IBADAN Brain Bank Project, a 43-item semi-structured interviewer-administered questionnaire was designed to evaluate knowledge, attitude, and beliefs of individuals attending Neurology, Psychiatry and Geriatrics Outpatient clinics regarding willingness to donate brain for research. Association between participants characteristics and willingness towards brain donation was investigated using logistic regression models. Analysis was conducted using Stata SE version 12.0. RESULTS: A total of 412 participants were interviewed. Their mean age was 46.3 (16.1) years. 229 (55.6%) were females and 92.5% had at least 6 years of formal education. Overall, 109 (26.7%) were willing to donate brains for research. In analyses adjusting for educational status, religion, ethnicity, marital status and family setting, male sex showed independent association with willingness towards brain donation OR (95% CI) 1.7 (1.08-2.69), p = 0.023. Participants suggested public engagement and education through mass media (including social media) and involvement of religious and community leaders as important interventions to improve awareness and willingness towards brain donation. CONCLUSION: The survey revealed low willingness among outpatient clinic attendees to donate brain for research, although men were more inclined to donate. It is imperative to institute public engagement and educational interventions in order to improve consent for brain donation for research.
BACKGROUND: Laboratory-based studies of neurological disease patterns and mechanisms are sparse in sub-Saharan Africa. However, availability of human brain tissue resource depends on willingness towards brain donation. This study evaluated the level of willingness among outpatient clinic attendees in a Nigerian teaching hospital. METHODS: Under the auspices of the IBADAN Brain Bank Project, a 43-item semi-structured interviewer-administered questionnaire was designed to evaluate knowledge, attitude, and beliefs of individuals attending Neurology, Psychiatry and Geriatrics Outpatient clinics regarding willingness to donate brain for research. Association between participants characteristics and willingness towards brain donation was investigated using logistic regression models. Analysis was conducted using Stata SE version 12.0. RESULTS: A total of 412 participants were interviewed. Their mean age was 46.3 (16.1) years. 229 (55.6%) were females and 92.5% had at least 6 years of formal education. Overall, 109 (26.7%) were willing to donate brains for research. In analyses adjusting for educational status, religion, ethnicity, marital status and family setting, male sex showed independent association with willingness towards brain donation OR (95% CI) 1.7 (1.08-2.69), p = 0.023. Participants suggested public engagement and education through mass media (including social media) and involvement of religious and community leaders as important interventions to improve awareness and willingness towards brain donation. CONCLUSION: The survey revealed low willingness among outpatient clinic attendees to donate brain for research, although men were more inclined to donate. It is imperative to institute public engagement and educational interventions in order to improve consent for brain donation for research.
Authors: D A Bennett; J A Schneider; Z Arvanitakis; J F Kelly; N T Aggarwal; R C Shah; R S Wilson Journal: Neurology Date: 2006-06-27 Impact factor: 9.910
Authors: Raj N Kalaria; Gladys E Maestre; Raul Arizaga; Robert P Friedland; Doug Galasko; Kathleen Hall; José A Luchsinger; Adesola Ogunniyi; Elaine K Perry; Felix Potocnik; Martin Prince; Robert Stewart; Anders Wimo; Zhen-Xin Zhang; Piero Antuono Journal: Lancet Neurol Date: 2008-07-28 Impact factor: 44.182
Authors: Rufus Olusola Akinyemi; Joshua Odunayo Akinyemi; Olorunyomi Felix Olorunsogbon; Ezinne Uvere; Ayodele Samuel Jegede; Oyedunni Sola Arulogun Journal: Pan Afr Med J Date: 2020-08-17