Ewa Sierko1,2, Ewa Zabrocka3, Krystyna Ostrowska-Cichocka4, Piotr Tokajuk5,4, Lech Zimnoch6, Marek Z Wojtukiewicz5,4. 1. Department of Oncology, Medical University, Bialystok, Poland ewa.sierko@iq.pl. 2. Department of Radiotherapy, Comprehensive Cancer Center, Bialystok, Poland. 3. Department of Medicine, Stony Brook University, Stony Brook, NY, U.S.A. 4. Department of Clinical Oncology, Comprehensive Cancer Center, Bialystok, Poland. 5. Department of Oncology, Medical University, Bialystok, Poland. 6. Department of Clinical Pathomorphology, Medical University, Bialystok, Poland.
Abstract
BACKGROUND/AIM: Hemostatic system components contribute to cancer progression independently from their roles in hemostasis. It has been shown that protein Z (PZ)/protein Z-dependent protease inhibitor (ZPI) inhibit coagulation factor X (FX). The aim of the study was to analyze the expression of PZ/ZPI in relation to the main coagulation factor - FX in human endometrial cancer tissue. MATERIALS AND METHODS: Immunohistochemical analysis was performed on 21 endometrial cancer specimens employing antibodies against ZPI, PZ and FX. RESULTS: Endometrial cancer cells showed a strong expression of ZPI and PZ and medium expression of FX. Normal endometrial tissue showed no expression of ZPI, PZ or FX. CONCLUSION: Strong expression of PZ and ZPI in endometrial cancer cells suggests a role of these proteins in endometrial cancer. Copyright
BACKGROUND/AIM: Hemostatic system components contribute to cancer progression independently from their roles in hemostasis. It has been shown that protein Z (PZ)/protein Z-dependent protease inhibitor (ZPI) inhibit coagulation factor X (FX). The aim of the study was to analyze the expression of PZ/ZPI in relation to the main coagulation factor - FX in humanendometrial cancer tissue. MATERIALS AND METHODS: Immunohistochemical analysis was performed on 21 endometrial cancer specimens employing antibodies against ZPI, PZ and FX. RESULTS:Endometrial cancer cells showed a strong expression of ZPI and PZ and medium expression of FX. Normal endometrial tissue showed no expression of ZPI, PZ or FX. CONCLUSION: Strong expression of PZ and ZPI in endometrial cancer cells suggests a role of these proteins in endometrial cancer. Copyright