Graziela Biude Silva Duarte1, Bruna Zavarize Reis2, Marcelo Macedo Rogero3, Ernesto Vargas-Mendez4, Fernando Barbosa Júnior5, Cintia Cercato6, Silvia Maria Franciscato Cozzolino2. 1. Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Science, University of São Paulo, São Paulo, Brazil. Electronic address: Gbiude@usp.br. 2. Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Science, University of São Paulo, São Paulo, Brazil. 3. Department of Nutrition, School of Public Health, University of São Paulo, São Paulo, Brazil; Food Research Center (FoRC), CEPID-FAPESP, Research Innovation and Dissemination Centers São Paulo Research Foundation, São Paulo, Brazil. 4. Department of Biochemistry, School of Medicine, University of Costa Rica, Costa Rica. 5. Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil. 6. Division of Endocrinology and Metabolism, Clinical Hospital, School of Medicine, University of São Paulo, São Paulo, Brazil.
Abstract
OBJECTIVE: Increased inflammatory response is an important factor in the pathophysiology of obesity. The mineral selenium (Se), of which one of the main food sources is the Brazil nut, has important antioxidant and anti-inflammatory functions through the action of selenoproteins. Thus, the evaluation of the influence of this micronutrient in this context is of great relevance. The aim of this study was to evaluate the effects of Brazil nut intake with high Se concentrations on inflammatory biomarkers and its relation to Se status in obese women. METHODS: A randomized controlled clinical trial was carried out with 55 women recruited at Clinical Hospital in São Paulo, Brazil. Patients were randomly assigned to either the Brazil nut group (BN) or the control group (CO) and followed up for 2 mo. The BN group consumed 1 unit/d of Brazil nuts (∼ 1261 μg/Se); the CO group did not receive any intervention. At baseline and after 2 mo, analysis of biochemical parameters related to Se status, oxidative stress, and inflammatory biomarkers were performed. RESULTS: At baseline, both groups did not present Se deficiency. In the BN group, a significant increase (P < 0.05) in all Se biomarkers and in gene expression of several proinflammatory parameters (interleukin-6, tumor necrosis factor-α, and Toll-like receptors 2 and 4) were observed after the intervention period. No changes were observed for the CO group. CONCLUSION: Although there were no changes in plasma inflammatory biomarkers levels, a significant increase in gene expression may be an indication of a proinflammatory stimulus in obesity, induced by the consumption of Brazil nuts with high Se levels.
RCT Entities:
OBJECTIVE: Increased inflammatory response is an important factor in the pathophysiology of obesity. The mineral selenium (Se), of which one of the main food sources is the Brazil nut, has important antioxidant and anti-inflammatory functions through the action of selenoproteins. Thus, the evaluation of the influence of this micronutrient in this context is of great relevance. The aim of this study was to evaluate the effects of Brazil nut intake with high Se concentrations on inflammatory biomarkers and its relation to Se status in obesewomen. METHODS: A randomized controlled clinical trial was carried out with 55 women recruited at Clinical Hospital in São Paulo, Brazil. Patients were randomly assigned to either the Brazil nut group (BN) or the control group (CO) and followed up for 2 mo. The BN group consumed 1 unit/d of Brazil nuts (∼ 1261 μg/Se); the CO group did not receive any intervention. At baseline and after 2 mo, analysis of biochemical parameters related to Se status, oxidative stress, and inflammatory biomarkers were performed. RESULTS: At baseline, both groups did not present Se deficiency. In the BN group, a significant increase (P < 0.05) in all Se biomarkers and in gene expression of several proinflammatory parameters (interleukin-6, tumor necrosis factor-α, and Toll-like receptors 2 and 4) were observed after the intervention period. No changes were observed for the CO group. CONCLUSION: Although there were no changes in plasma inflammatory biomarkers levels, a significant increase in gene expression may be an indication of a proinflammatory stimulus in obesity, induced by the consumption of Brazil nuts with high Se levels.
Authors: Larissa Cristina Fontenelle; Mickael de Paiva Sousa; Loanne Rocha Dos Santos; Bruna Emanuele Pereira Cardoso; Thayanne Gabryelle Visgueira de Sousa; Tamires da Cunha Soares; Stéfany Rodrigues de Sousa Melo; Jennifer Beatriz Silva Morais; Thaline Milany da Silva Dias; Francisco Erasmo de Oliveira; Débora Cavalcante Braz; João Marcelo de Castro E Sousa; Francisco Leonardo Torres-Leal; Gilberto Simeone Henriques; Dilina do Nascimento Marreiro Journal: Biol Trace Elem Res Date: 2022-04-06 Impact factor: 3.738
Authors: Stephanie K Nishi; Effie Viguiliouk; Sonia Blanco Mejia; Cyril W C Kendall; Richard P Bazinet; Anthony J Hanley; Elena M Comelli; Jordi Salas Salvadó; David J A Jenkins; John L Sievenpiper Journal: Obes Rev Date: 2021-09-08 Impact factor: 10.867
Authors: Alexey A Tinkov; Olga P Ajsuvakova; Tommaso Filippini; Ji-Chang Zhou; Xin Gen Lei; Eugenia R Gatiatulina; Bernhard Michalke; Margarita G Skalnaya; Marco Vinceti; Michael Aschner; Anatoly V Skalny Journal: Biomolecules Date: 2020-04-24
Authors: Leonardo W Lima; Gavin C Stonehouse; Christina Walters; Ali F El Mehdawi; Sirine C Fakra; Elizabeth A H Pilon-Smits Journal: Plants (Basel) Date: 2019-08-16