| Literature DB >> 31026486 |
Yinan Zhao1, Yanguo Xin2, Su Meng1, Zhiyi He1, Wenyu Hu3.
Abstract
The diagnostic value of neurofilament light chain protein in neurodegenerative dementia diseases is still controversial. A systematic literature search was performed to identify relevant case-control studies conducted through October 2018. Traditional and net meta-analyses were performed based on 42 studies that tested the diagnostic performance of neurofilament light chain protein (NfL) concentration in CSF and serum/plasma from patients with neurodegenerative dementia. CSF and serum/plasma NfL levels were significantly increased in patients with neurodegenerative dementia diseases. Network meta-analysis showed a significant reduction in CSF NfL levels during mild cognitive impairment, whereas an increase was observed in vascular dementia compared to Alzheimer's disease. Surface under the cumulative ranking curve and cluster analysis showed that the NfL concentration in CSF (vascular dementia, frontotemporal dementia, and Alzheimer's disease) and serum/plasma (frontotemporal dementia and Alzheimer's disease) ranked first among neurodegenerative dementia diseases. NfL is an important biomarker that can help clinical neurologists make early diagnoses of neurodegenerative diseases, so patients can receive prompt treatment.Entities:
Keywords: Alzheimer disease; Cerebrospinal Fluid; Dementia with Lewy bodies; Diagnosis; Frontotemporal Dementia; Meta-Analysis; Neurodegenerative dementia; Neurofilament Proteins; Plasma; Vascular Dementia
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Year: 2019 PMID： 31026486 DOI： 10.1016/j.neubiorev.2019.04.014
Source DB: PubMed Journal: Neurosci Biobehav Rev ISSN： 0149-7634 Impact factor: 8.989