Literature DB >> 3102424

Urinary bladder carcinogenesis by N-butyl-N-(4-hydroxybutyl)-nitrosamine in an analbuminemic congenic strain of rats with an ACI genetic background.

S Nagase, S Shumiya, M Takahashi, A Maekawa, Y Hayashi.   

Abstract

An analbuminemic congenic strain of rats originating from ACI (ACI-alb) rats was established. The rats were found to be highly susceptible to induction of urinary bladder cancer by N-butyl-N-(4-hydroxy-butyl)nitrosamine. Bladder cancers were observed in all male ACI-alb and normal ACI rats treated with the compound, but the average weight of the bladder including tumors was more in ACI-alb rats than in ACI rats (0.63 +/- 0.24 g and 0.18 +/- 0.05 g, respectively; ratio, 3.5:1).

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Year:  1986        PMID： 3102424

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  3 in total

1.  Identification of a protein increasing in serum of Nagase analbuminemic rats bearing intestinal tumors as an isotype of T-kininogen.

Authors:  S Kanda; K Sugiyama; M Takahashi; S Shumiya; S Tomino; S Nagase
Journal:  Jpn J Cancer Res       Date:  1990-01

Review 2.  Chemical carcinogenesis in analbuminemic rats.

Authors:  T Kakizoe; T Sugimura
Journal:  Jpn J Cancer Res       Date:  1988-07

3.  High susceptibility of an analbuminemic congenic strain of rats with an F344 genetic background to induced bladder cancer and its possible mechanism.

Authors:  M Takahashi; S Shumiya; A Maekawa; Y Hayashi; S Nagase
Journal:  Jpn J Cancer Res       Date:  1988-06
  3 in total

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