Literature DB >> 3102093

Inhibition of methionine uptake by methotrexate in mouse leukemia L1210 cells.

K J Scanlon, A R Cashmore, M Kashani-Sabet, M Pallai, R N Dreyer, B A Moroson, M Saketos.   

Abstract

Methionine-auxotrophic L1210 cells were used to study the effect of methotrexate (MTX) on methionine uptake and metabolism. MTX was shown to inhibit amino acid transport systems and cause a decrease of methionine uptake into L1210 cells. Conversely, a nonmetabolizable amino acid analogue reduced MTX uptake into L1210 cells. MTX also blocked the transfer of the beta carbon from serine into methionine. Therefore, methionine deprivation may be an additional mechanism of action for MTX in methionine-auxotrophic tumor cells.

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Year:  1987        PMID： 3102093     DOI： 10.1007/bf00296249

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN： 0344-5704            Impact factor:   3.333


  20 in total

1.  A bicyclic amino acid to improve discriminations among transport systems.

Authors:  H N Christensen; M E Handlogten; I Lam; H S Tager; R Zand
Journal:  J Biol Chem       Date:  1969-03-25       Impact factor: 5.157

2.  Carrier-mediated transport of the folic acid analogue, methotrexate, in the L1210 leukemia cell.

Authors:  I D Goldman; N S Lichtenstein; V T Oliverio
Journal:  J Biol Chem       Date:  1968-10-10       Impact factor: 5.157

3.  The diuretic and natruretic activity of triamterene and several related pteridines in the rat.

Authors:  V D Wiebelhaus; J Weinstock; A B Maass; F T Brennan; G Sosnowski; T Larsen
Journal:  J Pharmacol Exp Ther       Date:  1965-09       Impact factor: 4.030

Review 4.  Methionine dependence in cancer cells - a review.

Authors:  R M Hoffman
Journal:  In Vitro       Date:  1982-05

5.  Inhibition of serine metabolism by tetrahydrohomofolate in L1210 mouse leukemia cells.

Authors:  K J Scanlon; A R Cashmore; B A Moroson; R N Dreyer; J R Bertino
Journal:  Mol Pharmacol       Date:  1981-05       Impact factor: 4.436

Review 6.  Interorgan amino acid nutrition.

Authors:  H N Christensen
Journal:  Physiol Rev       Date:  1982-10       Impact factor: 37.312

7.  Establishment of methotrexate-resistant human acute lymphoblastic leukemia cells in culture and effects of folate antagonists.

Authors:  T Ohnoshi; T Ohnuma; I Takahashi; K Scanlon; B A Kamen; J F Holland
Journal:  Cancer Res       Date:  1982-05       Impact factor: 12.701

8.  Methionine dependency of cell growth in normal and malignant hematopoietic cells.

Authors:  Y Kano; S Sakamoto; T Kasahara; K Kusumoto; K Hida; K Suda; K Ozawa; Y Miura; F Takaku
Journal:  Cancer Res       Date:  1982-08       Impact factor: 12.701

9.  Effects of methotrexate on folates in Krebs ascites and L1210 murine leukemia cells.

Authors:  V Kesavan; P Sur; M T Doig; K J Scanlon; D G Priest
Journal:  Cancer Lett       Date:  1986-01       Impact factor: 8.679

10.  Properties of amino acid transport systems in K562 cells sensitive and resistant to cis-diamminedichloroplatinum(II).

Authors:  S Shionoya; Y Lu; K J Scanlon
Journal:  Cancer Res       Date:  1986-07       Impact factor: 12.701
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  3 in total

1.  Elevated expression of thymidylate synthase cycle genes in cisplatin-resistant human ovarian carcinoma A2780 cells.

Authors:  K J Scanlon; M Kashani-Sabet
Journal:  Proc Natl Acad Sci U S A       Date:  1988-02       Impact factor: 11.205

2.  Amplification of the thymidylate synthase gene in an N10-propargyl-5,8-dideazafolic-acid-resistant human leukemia, MOLT-3 cell line developed in pteroylglutamic acid, but not in leucovorin.

Authors:  H Miyachi; Y Takemura; H Kobayashi; Y Ando
Journal:  J Cancer Res Clin Oncol       Date:  1996       Impact factor: 4.553

3.  The role of folates in the development of methotrexate resistance in human leukemia cell line K562.

Authors:  H Miyachi; Y Takemura; Y Ando; K J Scanlon
Journal:  J Cancer Res Clin Oncol       Date:  1992       Impact factor: 4.553
  3 in total

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