| Literature DB >> 31020666 |
Angela Adamski da Silva Reis1,2, Keila Correia de Alcântara3, Danielle Leão Cordeiro de Farias4, Laura Raniere Borges Dos Anjos1, Débora Acyole Rodrigues1, Gustavo Rodrigues Pedrino2, Rodrigo da Silva Santos1,5.
Abstract
Some factors have been associated with the etiology of chronic lymphocytic leukemia (CLL), among them the Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism. The aim of this study was to evaluate the role of MTHFR C677T polymorphism in CLL. A case-control study was conducted with 219 individuals from Brazilian central population. MTHFR C677T polymorphism was determined through PCR-RFLP followed by PAGE. The T allele frequence was higher in patients diagnosed with CLL than healthy subjects. However, when stratified by gender, the TT genotype was exclusively found in men diagnosed with CLL (p < 0.05). Adjusted multiple logistic regression analysis demonstrated that age was significantly linked to CLL predisposition (odds ratio = 1.08; p < 0.001). Studies evaluating the influence of genetic factors may provide insights on susceptibility for CLL.Entities:
Keywords: Central Brazilian population; Chronic lymphocytic leukemia; Methylenetetrahydrofolate reductase C677T polymorphism
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Year: 2019 PMID： 31020666 DOI： 10.1002/elps.201800402
Source DB: PubMed Journal: Electrophoresis ISSN： 0173-0835 Impact factor: 3.535