Literature DB >> 3101929

Feedback control of arterial smooth muscle tone: the role of prostacyclin.

P Hadházy, K Magyar.   

Abstract

Indomethacin potentiated noradrenaline (NA)-induced contractions of rabbit isolated mesenteric arteries. Mechanical removal of the endothelium did not influence its potentiating effect. Prostacyclin (PGI2) synthesis was stimulated by NA (0.1-1.0 mumol l-1) and inhibited by indomethacin in a concentration-dependent manner. There was a positive correlation between the indomethacin-induced inhibition of PGI2 formation and the indomethacin-evoked potentiation of contractile responses to NA. These results suggest that endogenous PGI2 plays a part in the feedback control of vascular smooth muscle tone.

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Year:  1986        PMID： 3101929      PMCID： PMC1917248          DOI： 10.1111/j.1476-5381.1986.tb11192.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  8 in total

1.  Characterization of prostacyclin synthesis in cultured human arterial smooth muscle cells, venous endothelial cells and skin fibroblasts.

Authors:  N L Baenziger; P R Becherer; P W Majerus
Journal:  Cell       Date:  1979-04       Impact factor: 41.582

2.  Differential contractile responsiveness of isolated rabbit arteries from different vascular beds to cyclooxygenase inhibitors and PGI2.

Authors:  P Hadházy; B Malomvölgyi; K Magyar
Journal:  Eur J Pharmacol       Date:  1984-03-02       Impact factor: 4.432

3.  The importance of endogenous prostaglandins other than prostacyclin, for the modulation of contractility of some rabbit blood vessels.

Authors:  U Förstermann; G Hertting; B Neufang
Journal:  Br J Pharmacol       Date:  1984-04       Impact factor: 8.739

4.  The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine.

Authors:  R F Furchgott; J V Zawadzki
Journal:  Nature       Date:  1980-11-27       Impact factor: 49.962

5.  Modification by prostaglandins E1 and E2, indomethacin, and arachidonic acid of the vasoconstrictor responses of the isolated perfused rabbit and rat mesenteric arteries to adrenergic stimuli.

Authors:  K U Malik; P Ryan; J C McGiff
Journal:  Circ Res       Date:  1976-08       Impact factor: 17.367

6.  Effects of nerve stimulation and of administration of noradrenaline or potassium chloride upon the release of prostaglandins, I2, E2, and F2 alpha from te perfused mesenteric arterial bed of the rabbit.

Authors:  E Pipili; N L Poyser
Journal:  Br J Pharmacol       Date:  1981-01       Impact factor: 8.739

7.  Effect of angiotensin ii and norepinephrine on release of prostaglandins E2 and I2 by the perfused rat mesenteric artery.

Authors:  S Desjardins-Giasson; J Gutkowska; R Garcia; J Genest
Journal:  Prostaglandins       Date:  1982-07

8.  Prostacyclin production by cultured smooth muscle cells from atherosclerotic rabbit aorta.

Authors:  J Larrue; M Rigaud; D Daret; J Demond; J Durand; H Bricaud
Journal:  Nature       Date:  1980-06-12       Impact factor: 49.962
  8 in total
  1 in total

1.  Multiple actions of halothane on contractile response to noradrenaline in isolated mesenteric resistance arteries.

Authors:  J Yoshino; T Akata; K Izumi; S Takahashi
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2005-07-13       Impact factor: 3.000
  1 in total

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